Bilayer degradation in reactive environments

Lipid vesicles, or liposomes have been widely studied both as a model for cell membranes and for applications such as drug delivery. As a rule, their aqueous environment (in vitro or in vivo) contains various degradation agents, ranging from free radicals to acids and enzymes. This paper investigate...

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Main Author:	Nily Dan
Format:	Article
Language:	English
Published:	AIMS Press 2016-12-01
Series:	AIMS Biophysics
Subjects:	three-dimensional (3D) Monte Carlo simulations vesicles liposomes bilayers degradation
Online Access:	http://www.aimspress.com/biophysics/article/1180/fulltext.html

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spelling	doaj-c7cc9d6d98d446d6b5f4d76aa1cf0f8c2020-11-24T21:55:28ZengAIMS PressAIMS Biophysics2377-90982016-12-0141334210.3934/biophy.2017.1.33biophys-04-00033Bilayer degradation in reactive environmentsNily Dan0Department of Chemical and Biological Engineering, Drexel University, 3101 Chestnut St, Philadelphia PA 19104, USALipid vesicles, or liposomes have been widely studied both as a model for cell membranes and for applications such as drug delivery. As a rule, their aqueous environment (in vitro or in vivo) contains various degradation agents, ranging from free radicals to acids and enzymes. This paper investigates the degradation of lipid vesicles as a function of environmental conditions using 3d Monte-Carlo simulations. The time-scale for bilayer degradation is found to be independent of the liposome size, but highly sensitive to the concentration of degradation molecules in solution and to the rate of the degradation reaction.http://www.aimspress.com/biophysics/article/1180/fulltext.htmlthree-dimensional (3D) Monte Carlo simulationsvesiclesliposomesbilayersdegradation
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nily Dan
spellingShingle	Nily Dan Bilayer degradation in reactive environments AIMS Biophysics three-dimensional (3D) Monte Carlo simulations vesicles liposomes bilayers degradation
author_facet	Nily Dan
author_sort	Nily Dan
title	Bilayer degradation in reactive environments
title_short	Bilayer degradation in reactive environments
title_full	Bilayer degradation in reactive environments
title_fullStr	Bilayer degradation in reactive environments
title_full_unstemmed	Bilayer degradation in reactive environments
title_sort	bilayer degradation in reactive environments
publisher	AIMS Press
series	AIMS Biophysics
issn	2377-9098
publishDate	2016-12-01
description	Lipid vesicles, or liposomes have been widely studied both as a model for cell membranes and for applications such as drug delivery. As a rule, their aqueous environment (in vitro or in vivo) contains various degradation agents, ranging from free radicals to acids and enzymes. This paper investigates the degradation of lipid vesicles as a function of environmental conditions using 3d Monte-Carlo simulations. The time-scale for bilayer degradation is found to be independent of the liposome size, but highly sensitive to the concentration of degradation molecules in solution and to the rate of the degradation reaction.
topic	three-dimensional (3D) Monte Carlo simulations vesicles liposomes bilayers degradation
url	http://www.aimspress.com/biophysics/article/1180/fulltext.html
work_keys_str_mv	AT nilydan bilayerdegradationinreactiveenvironments
_version_	1725862441527541760

Bilayer degradation in reactive environments

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