EpCAM as Modulator of Tissue Plasticity

The Epithelial Cell Adhesion Molecule or EpCAM is a well-known marker highly expressed in carcinomas and showing a strong correlation with poor cancer prognosis. While its name relates to its proposed function as a cell adhesion molecule, EpCAM has been shown to have various signalling functions. In...

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Main Author:	François Fagotto
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Series:	Cells
Subjects:	Epithelial Cell Adhesion Molecule Trop1 Trop2 TACSD metastasis cell–cell adhesion
Online Access:	https://www.mdpi.com/2073-4409/9/9/2128

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spelling	doaj-c7cfb96c1a714bf4b87e9db5ff5521052020-11-25T03:22:01ZengMDPI AGCells2073-44092020-09-0192128212810.3390/cells9092128EpCAM as Modulator of Tissue PlasticityFrançois Fagotto0CRBM, University of Montpellier and CNRS, 34293 Montpellier, FranceThe Epithelial Cell Adhesion Molecule or EpCAM is a well-known marker highly expressed in carcinomas and showing a strong correlation with poor cancer prognosis. While its name relates to its proposed function as a cell adhesion molecule, EpCAM has been shown to have various signalling functions. In particular, it has been identified as an important positive regulator of cell adhesion and migration, playing an essential role in embryonic morphogenesis as well as intestinal homeostasis. This activity is not due to its putative adhesive function, but rather to its ability to repress myosin contractility by impinging on a PKC signalling cascade. This mechanism confers EpCAM the unique property of favouring tissue plasticity. I review here the currently available data, comment on possible connections with other properties of EpCAM, and discuss the potential significance in the context of cancer invasion.https://www.mdpi.com/2073-4409/9/9/2128Epithelial Cell Adhesion MoleculeTrop1Trop2TACSDmetastasiscell–cell adhesion
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	François Fagotto
spellingShingle	François Fagotto EpCAM as Modulator of Tissue Plasticity Cells Epithelial Cell Adhesion Molecule Trop1 Trop2 TACSD metastasis cell–cell adhesion
author_facet	François Fagotto
author_sort	François Fagotto
title	EpCAM as Modulator of Tissue Plasticity
title_short	EpCAM as Modulator of Tissue Plasticity
title_full	EpCAM as Modulator of Tissue Plasticity
title_fullStr	EpCAM as Modulator of Tissue Plasticity
title_full_unstemmed	EpCAM as Modulator of Tissue Plasticity
title_sort	epcam as modulator of tissue plasticity
publisher	MDPI AG
series	Cells
issn	2073-4409
publishDate	2020-09-01
description	The Epithelial Cell Adhesion Molecule or EpCAM is a well-known marker highly expressed in carcinomas and showing a strong correlation with poor cancer prognosis. While its name relates to its proposed function as a cell adhesion molecule, EpCAM has been shown to have various signalling functions. In particular, it has been identified as an important positive regulator of cell adhesion and migration, playing an essential role in embryonic morphogenesis as well as intestinal homeostasis. This activity is not due to its putative adhesive function, but rather to its ability to repress myosin contractility by impinging on a PKC signalling cascade. This mechanism confers EpCAM the unique property of favouring tissue plasticity. I review here the currently available data, comment on possible connections with other properties of EpCAM, and discuss the potential significance in the context of cancer invasion.
topic	Epithelial Cell Adhesion Molecule Trop1 Trop2 TACSD metastasis cell–cell adhesion
url	https://www.mdpi.com/2073-4409/9/9/2128
work_keys_str_mv	AT francoisfagotto epcamasmodulatoroftissueplasticity
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EpCAM as Modulator of Tissue Plasticity

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