Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models

Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models

Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes. Discoveries using mouse NK cells have guided subsequent advances in human NK cell biology. However, it remains challenging to identify mou...

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Bibliographic Details
Main Author: Dorothy K. Sojka
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
conventional NK cells
pregnancy
maternal-fetal interface
tissue-resident NK cells
uterine NK cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00290/full
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spelling doaj-c7d8e6f543e74f6da736bca155bcb2502020-11-25T01:25:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-02-011110.3389/fimmu.2020.00290518203Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse ModelsDorothy K. SojkaNatural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes. Discoveries using mouse NK cells have guided subsequent advances in human NK cell biology. However, it remains challenging to identify mouse and human uterine NK (uNK) cell function(s) because of the dynamic changes in the systemic-endocrinological and local uterine structural microenvironments during pregnancy. This review discusses functional similarities and differences between mouse and human NK cells at the maternal-fetal interface.https://www.frontiersin.org/article/10.3389/fimmu.2020.00290/fullconventional NK cellspregnancymaternal-fetal interfacetissue-resident NK cellsuterine NK cells
collection DOAJ
language English
format Article
sources DOAJ
author Dorothy K. Sojka
spellingShingle Dorothy K. Sojka
Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models
Frontiers in Immunology
conventional NK cells
pregnancy
maternal-fetal interface
tissue-resident NK cells
uterine NK cells
author_facet Dorothy K. Sojka
author_sort Dorothy K. Sojka
title Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models
title_short Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models
title_full Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models
title_fullStr Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models
title_full_unstemmed Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models
title_sort uterine natural killer cell heterogeneity: lessons from mouse models
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2020-02-01
description Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes. Discoveries using mouse NK cells have guided subsequent advances in human NK cell biology. However, it remains challenging to identify mouse and human uterine NK (uNK) cell function(s) because of the dynamic changes in the systemic-endocrinological and local uterine structural microenvironments during pregnancy. This review discusses functional similarities and differences between mouse and human NK cells at the maternal-fetal interface.
topic conventional NK cells
pregnancy
maternal-fetal interface
tissue-resident NK cells
uterine NK cells
url https://www.frontiersin.org/article/10.3389/fimmu.2020.00290/full
work_keys_str_mv AT dorothyksojka uterinenaturalkillercellheterogeneitylessonsfrommousemodels
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