Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease
Abstract Background Acute cerebrovascular disease (ACVD) could cause abnormal metabolism of thyroid hormones (TH), mostly represented as a euthyroid sick syndrome or low T3 syndrome. However, the changes in serum thyroid-stimulating hormone (TSH) are controversial. The aim of this study is to invest...
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doaj-c7f1ecc2dce845d3acb7ce11b069c2722020-11-25T03:43:27ZengBMCEuropean Journal of Medical Research2047-783X2019-10-012411710.1186/s40001-019-0395-4Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular diseaseJian Zhu0Ming Chen1Nan Li2Shaoling Yang3Lu Xu4Yanru Wang5Hong Li6Department of Neurology, Dachang Hospital of Baoshan DistrictDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of MedicineAbstract Background Acute cerebrovascular disease (ACVD) could cause abnormal metabolism of thyroid hormones (TH), mostly represented as a euthyroid sick syndrome or low T3 syndrome. However, the changes in serum thyroid-stimulating hormone (TSH) are controversial. The aim of this study is to investigate the clinical significance of TSH alteration in patients with ACVD. Method Patients with ACVD admitted in our hospitals between January 2013 and September 2017 were enrolled in this study (n = 245, including 176 cerebral infarctions and 69 cerebral hemorrhages). Their thyroid hormones were measured and compared with healthy individuals (n = 75). The correlation of TSH with severity and prognosis of ACVD were analyzed by receiver operating characteristic curve. Results Serum TSH in ACVD group was higher than the control group (1.64 ± 1.08 vs. 1.26 ± 0.36 μIU/mL, P < 0.05). The TSH levels in intermediate and severe patients with ACVD were higher than in mild patients (1.72 ± 1.18 vs. 2.71 ± 0.93 vs. 1.02 ± 0.47 μIU/mL, P < 0.05). Receiver Operating Characteristic curve (ROC) of TSH in determining the severity of patients were 0.863 (Area under the curve, AUC), 1.496 μIU/L (optimal threshold), 76.5% (sensitivity) and 87.3% (specificity). TSH levels in improved and unchanged groups were significantly higher than the primarily healing group (2.27 ± 1.11 vs. 2.88 ± 1.07 vs. 0.86 ± 0.46 μIU/mL, P < 0.05). ROC of TSH in determining the prognosis of patients was 0.910 (AUC), 1.681 mIU/L (optimal threshold), 79.8% (sensitivity) and 90.5% (specificity) correspondingly. Conclusion Since elevated TSH in ACVD patients affects the outcome of thyroid function evaluation, it is preferable to re-check after the acute period. A correlation between a high TSH level and the severity and prognosis of ACVD was detected, but the mechanism of this correlation needs to be further studied.http://link.springer.com/article/10.1186/s40001-019-0395-4Acute cerebrovascular diseaseThyroid stimulating hormoneCerebral infarctionCerebral hemorrhageSeverityPrognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jian Zhu Ming Chen Nan Li Shaoling Yang Lu Xu Yanru Wang Hong Li |
spellingShingle |
Jian Zhu Ming Chen Nan Li Shaoling Yang Lu Xu Yanru Wang Hong Li Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease European Journal of Medical Research Acute cerebrovascular disease Thyroid stimulating hormone Cerebral infarction Cerebral hemorrhage Severity Prognosis |
author_facet |
Jian Zhu Ming Chen Nan Li Shaoling Yang Lu Xu Yanru Wang Hong Li |
author_sort |
Jian Zhu |
title |
Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease |
title_short |
Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease |
title_full |
Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease |
title_fullStr |
Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease |
title_full_unstemmed |
Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease |
title_sort |
correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease |
publisher |
BMC |
series |
European Journal of Medical Research |
issn |
2047-783X |
publishDate |
2019-10-01 |
description |
Abstract Background Acute cerebrovascular disease (ACVD) could cause abnormal metabolism of thyroid hormones (TH), mostly represented as a euthyroid sick syndrome or low T3 syndrome. However, the changes in serum thyroid-stimulating hormone (TSH) are controversial. The aim of this study is to investigate the clinical significance of TSH alteration in patients with ACVD. Method Patients with ACVD admitted in our hospitals between January 2013 and September 2017 were enrolled in this study (n = 245, including 176 cerebral infarctions and 69 cerebral hemorrhages). Their thyroid hormones were measured and compared with healthy individuals (n = 75). The correlation of TSH with severity and prognosis of ACVD were analyzed by receiver operating characteristic curve. Results Serum TSH in ACVD group was higher than the control group (1.64 ± 1.08 vs. 1.26 ± 0.36 μIU/mL, P < 0.05). The TSH levels in intermediate and severe patients with ACVD were higher than in mild patients (1.72 ± 1.18 vs. 2.71 ± 0.93 vs. 1.02 ± 0.47 μIU/mL, P < 0.05). Receiver Operating Characteristic curve (ROC) of TSH in determining the severity of patients were 0.863 (Area under the curve, AUC), 1.496 μIU/L (optimal threshold), 76.5% (sensitivity) and 87.3% (specificity). TSH levels in improved and unchanged groups were significantly higher than the primarily healing group (2.27 ± 1.11 vs. 2.88 ± 1.07 vs. 0.86 ± 0.46 μIU/mL, P < 0.05). ROC of TSH in determining the prognosis of patients was 0.910 (AUC), 1.681 mIU/L (optimal threshold), 79.8% (sensitivity) and 90.5% (specificity) correspondingly. Conclusion Since elevated TSH in ACVD patients affects the outcome of thyroid function evaluation, it is preferable to re-check after the acute period. A correlation between a high TSH level and the severity and prognosis of ACVD was detected, but the mechanism of this correlation needs to be further studied. |
topic |
Acute cerebrovascular disease Thyroid stimulating hormone Cerebral infarction Cerebral hemorrhage Severity Prognosis |
url |
http://link.springer.com/article/10.1186/s40001-019-0395-4 |
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