Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high‐anticoagulant thrombin‐binding bivalent DNA aptamer‐linked M08 with HD22

Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high‐anticoagulant thrombin‐binding bivalent DNA aptamer‐linked M08 with HD22

Abstract Background Bivalent thrombin‐binding aptamers (TBAs) have great potential for the treatment of thrombosis because they exhibit high anticoagulant activity, and their complementary single‐stranded DNA (ssDNA) sequences work as an antidote. However, a design strategy for antidote sequences ag...

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Bibliographic Details
Main Authors: Toru Yoshitomi, Koji Wakui, Masato Miyakawa, Keitaro Yoshimoto
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
anticoagulant
antidote
DNA aptamer
thrombin
Online Access:https://doi.org/10.1002/rth2.12503

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