Microbubble-Mediated Delivery for Cancer Therapy
Despite an overall improvement in survival rates for cancer, certain resistant forms of the disease still impose a significant burden on patients and healthcare systems. Standard chemotherapy in these cases is often ineffective and/or gives rise to severe side effects. Targeted delivery of chemother...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Fluids |
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| Online Access: | http://www.mdpi.com/2311-5521/3/4/74 |
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doaj-c7f5eab47fd54cc8b172335539dda2512020-11-24T21:00:31ZengMDPI AGFluids2311-55212018-10-01347410.3390/fluids3040074fluids3040074Microbubble-Mediated Delivery for Cancer TherapyRichard J. Browning0Eleanor Stride1Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus, Oxford OX3 7DQ, UKInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus, Oxford OX3 7DQ, UKDespite an overall improvement in survival rates for cancer, certain resistant forms of the disease still impose a significant burden on patients and healthcare systems. Standard chemotherapy in these cases is often ineffective and/or gives rise to severe side effects. Targeted delivery of chemotherapeutics could improve both tumour response and patient experience. Hence, there is an urgent need to develop effective methods for this. Ultrasound is an established technique in both diagnosis and therapy. Its use in conjunction with microbubbles is being actively researched for the targeted delivery of small-molecule drugs. In this review, we cover the methods by which ultrasound and microbubbles can be used to overcome tumour barriers to cancer therapy.http://www.mdpi.com/2311-5521/3/4/74ultrasoundcancerdrug deliverycavitationmicrobubbles |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Richard J. Browning Eleanor Stride |
| spellingShingle |
Richard J. Browning Eleanor Stride Microbubble-Mediated Delivery for Cancer Therapy Fluids ultrasound cancer drug delivery cavitation microbubbles |
| author_facet |
Richard J. Browning Eleanor Stride |
| author_sort |
Richard J. Browning |
| title |
Microbubble-Mediated Delivery for Cancer Therapy |
| title_short |
Microbubble-Mediated Delivery for Cancer Therapy |
| title_full |
Microbubble-Mediated Delivery for Cancer Therapy |
| title_fullStr |
Microbubble-Mediated Delivery for Cancer Therapy |
| title_full_unstemmed |
Microbubble-Mediated Delivery for Cancer Therapy |
| title_sort |
microbubble-mediated delivery for cancer therapy |
| publisher |
MDPI AG |
| series |
Fluids |
| issn |
2311-5521 |
| publishDate |
2018-10-01 |
| description |
Despite an overall improvement in survival rates for cancer, certain resistant forms of the disease still impose a significant burden on patients and healthcare systems. Standard chemotherapy in these cases is often ineffective and/or gives rise to severe side effects. Targeted delivery of chemotherapeutics could improve both tumour response and patient experience. Hence, there is an urgent need to develop effective methods for this. Ultrasound is an established technique in both diagnosis and therapy. Its use in conjunction with microbubbles is being actively researched for the targeted delivery of small-molecule drugs. In this review, we cover the methods by which ultrasound and microbubbles can be used to overcome tumour barriers to cancer therapy. |
| topic |
ultrasound cancer drug delivery cavitation microbubbles |
| url |
http://www.mdpi.com/2311-5521/3/4/74 |
| work_keys_str_mv |
AT richardjbrowning microbubblemediateddeliveryforcancertherapy AT eleanorstride microbubblemediateddeliveryforcancertherapy |
| _version_ |
1716779564731990016 |