Reproducibility of Gadolinium Enhancement Patterns and Wall Thickness in Hypertrophic Cardiomyopathy

• Main Authors: Gaston A. Rodriguez-Granillo, Alejandro Deviggiano, Carlos Capunay, Macarena C. De Zan, Patricia Carrascosa
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Cardiologia (SBC) 2016-01-01
• Series: Arquivos Brasileiros de Cardiologia
• Subjects: Cardiomiopatia Hipertrófica; Reprodutibilidade dos Testes; Gadolínio; Disfunção Ventricular; Imagem por Ressonância Magnética
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016005016104&lng=en&tlng=en

Abstract Background: Reproducibility data of the extent and patterns of late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) is limited. Objective: To explore the reproducibility of regional wall thickness (WT), LGE extent, and LGE patterns in patients with HCM assessed with cardiac magnetic resonance (CMR). Methods: The extent of LGE was assessed by the number of segments with LGE, and by the total LV mass with LGE (% LGE); and the pattern of LGE-CMR was defined for each segment. Results: A total of 42 patients (672 segments) with HCM constituted the study population. The mean WT measurements showed a mean difference between observers of -0.62 ± 1.0 mm (6.1%), with limits of agreement of 1.36 mm; -2.60 mm and intraclass correlation coefficient (ICC) of 0.95 (95% CI 0.93-0.96). Maximum WT measurements showed a mean difference between observers of -0.19 ± 0.8 mm (0.9%), with limits of agreement of 1.32 mm; -1.70 mm, and an ICC of 0.95 (95% CI 0.91-0.98). The % LGE showed a mean difference between observers of -1.17 ± 1.2 % (21%), with limits of agreement of 1.16%; -3.49%, and an ICC of 0.94 (95% CI 0.88-0.97). The mean difference between observers regarding the number of segments with LGE was -0.40 ± 0.45 segments (11%), with limits of agreement of 0.50 segments; -1.31 segments, and an ICC of 0.97 (95% CI 0.94-0.99). Conclusions: The number of segments with LGE might be more reproducible than the percent of the LV mass with LGE.