The Association of <em>TMPRSS6</em> Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, Indonesia
Multiple common variants in <i>transmembrane protease serine 6 (TMPRSS6)</i> were associated with the plasma iron concentration in genome-wide association studies, but their effect in young children where anemia and iron deficiency (ID) were prevalent has not been reported, particularly...
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doaj-c7ff3a2408054a7aac1013873c18fe342020-11-24T20:42:09ZengMDPI AGNutrients2072-66432019-04-0111487810.3390/nu11040878nu11040878The Association of <em>TMPRSS6</em> Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, IndonesiaDewi Shinta0Asmarinah1Chris Adhiyanto2Min Kyaw Htet3Umi Fahmida4Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON) Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta 10430, IndonesiaDepartment of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaFaculty of Medicine, Universitas Islam Negeri Syarif Hidayatullah, Jakarta 15412, IndonesiaSoutheast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON) Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta 10430, IndonesiaSoutheast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON) Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta 10430, IndonesiaMultiple common variants in <i>transmembrane protease serine 6 (TMPRSS6)</i> were associated with the plasma iron concentration in genome-wide association studies, but their effect in young children where anemia and iron deficiency (ID) were prevalent has not been reported, particularly taking account of iron intake. This study aims to investigate whether <i>TMPRSS6</i> SNPs (rs855791 and rs4820268) and iron intake are associated with a low iron and hemoglobin concentration in under-two-year-old children. The study analyzed the baseline of a randomized trial (NUPICO, ClinicalTrials.gov NCT01504633) in East Lombok, Indonesia. Children aged 6–17 months (<i>n</i> = 121) were included in this study. The multiple linear regressions showed that <i>TMPRSS6</i> decreased serum ferritin (SF) by 4.50 g/L per copy minor allele (A) of rs855791 (<i>p</i> = 0.08) and by 5.00 μg/L per copy minor allele (G) of rs4820268 (<i>p</i> = 0.044). There were no associations between rs855791 and rs4820268 with soluble transferrin receptor (sTfR) and hemoglobin (Hb) concentration (rs855791; <i>p</i> = 0.38 and <i>p</i> = 0.13, rs4820268; <i>p</i> = 0.17 and <i>p</i> = 0.33). The finding suggests the need for further studies to explore whether the nutrient recommendation for iron should be based on genetic characteristics, particularly for children who have mutation in <i>TMPRSS6</i>.https://www.mdpi.com/2072-6643/11/4/878anemiairon deficiency<i>TMPRSS6</i>iron intakechildrenIndonesia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dewi Shinta Asmarinah Chris Adhiyanto Min Kyaw Htet Umi Fahmida |
spellingShingle |
Dewi Shinta Asmarinah Chris Adhiyanto Min Kyaw Htet Umi Fahmida The Association of <em>TMPRSS6</em> Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, Indonesia Nutrients anemia iron deficiency <i>TMPRSS6</i> iron intake children Indonesia |
author_facet |
Dewi Shinta Asmarinah Chris Adhiyanto Min Kyaw Htet Umi Fahmida |
author_sort |
Dewi Shinta |
title |
The Association of <em>TMPRSS6</em> Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, Indonesia |
title_short |
The Association of <em>TMPRSS6</em> Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, Indonesia |
title_full |
The Association of <em>TMPRSS6</em> Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, Indonesia |
title_fullStr |
The Association of <em>TMPRSS6</em> Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, Indonesia |
title_full_unstemmed |
The Association of <em>TMPRSS6</em> Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, Indonesia |
title_sort |
association of <em>tmprss6</em> gene polymorphism and iron intake with iron status among under-two-year-old children in lombok, indonesia |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-04-01 |
description |
Multiple common variants in <i>transmembrane protease serine 6 (TMPRSS6)</i> were associated with the plasma iron concentration in genome-wide association studies, but their effect in young children where anemia and iron deficiency (ID) were prevalent has not been reported, particularly taking account of iron intake. This study aims to investigate whether <i>TMPRSS6</i> SNPs (rs855791 and rs4820268) and iron intake are associated with a low iron and hemoglobin concentration in under-two-year-old children. The study analyzed the baseline of a randomized trial (NUPICO, ClinicalTrials.gov NCT01504633) in East Lombok, Indonesia. Children aged 6–17 months (<i>n</i> = 121) were included in this study. The multiple linear regressions showed that <i>TMPRSS6</i> decreased serum ferritin (SF) by 4.50 g/L per copy minor allele (A) of rs855791 (<i>p</i> = 0.08) and by 5.00 μg/L per copy minor allele (G) of rs4820268 (<i>p</i> = 0.044). There were no associations between rs855791 and rs4820268 with soluble transferrin receptor (sTfR) and hemoglobin (Hb) concentration (rs855791; <i>p</i> = 0.38 and <i>p</i> = 0.13, rs4820268; <i>p</i> = 0.17 and <i>p</i> = 0.33). The finding suggests the need for further studies to explore whether the nutrient recommendation for iron should be based on genetic characteristics, particularly for children who have mutation in <i>TMPRSS6</i>. |
topic |
anemia iron deficiency <i>TMPRSS6</i> iron intake children Indonesia |
url |
https://www.mdpi.com/2072-6643/11/4/878 |
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