Development of an HPLC-MS/MS Method for the Determination of Silybin in Human Plasma, Urine and Breast Tissue

Development of an HPLC-MS/MS Method for the Determination of Silybin in Human Plasma, Urine and Breast Tissue

Silybin is a flavonolignan extracted from <i>Silybum marianum</i> with chemopreventive activity against various cancers, including breast. This study was designed to develop an HPLC-MS/MS method for the determination of silybin in human plasma, urine and breast tissue in early breast can...

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Bibliographic Details
Main Authors: Matteo Lazzeroni, Giovanna Petrangolini, José Antonio Legarreta Iriberri, Jaume Pascual Avellana, Digna Tost Robusté, Sara Cagnacci, Debora Macis, Valentina Aristarco, Bernardo Bonanni, Paolo Morazzoni, Harriet Johansson, Antonella Riva
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
silybin
silibinin
Siliphos<sup>®</sup>
breast cancer
HPLC-MS/MS method
Online Access:https://www.mdpi.com/1420-3049/25/12/2918

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