Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria
Pathogenic mycobacteria species may subvert the innate immune mechanisms and can modulate the activation of cells that cause disease in the skin. Cutaneous mycobacterial infection may present different clinical presentations and it is associated with stigma, deformity, and disability. The understand...
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doaj-c81055c21c184bb9a38f56c9556ec5ea2021-05-25T07:46:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-05-011210.3389/fimmu.2021.674241674241Autophagy as a Target for Drug Development Of Skin Infection Caused by MycobacteriaTamiris Lameira Bittencourt0Rhana Berto da Silva Prata1Bruno Jorge de Andrade Silva2Mayara Garcia de Mattos Barbosa3Margareth Pretti Dalcolmo4Roberta Olmo Pinheiro5Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, BrazilDivision of Dermatology, David Geffen School of Medicine, Los Angeles, CA, United StatesDepartment of Surgery, University of Michigan, Ann Arbor, MI, United StatesHelio Fraga Reference Center, Sergio Arouca National School of Public Health, Fiocruz, Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, BrazilPathogenic mycobacteria species may subvert the innate immune mechanisms and can modulate the activation of cells that cause disease in the skin. Cutaneous mycobacterial infection may present different clinical presentations and it is associated with stigma, deformity, and disability. The understanding of the immunopathogenic mechanisms related to mycobacterial infection in human skin is of pivotal importance to identify targets for new therapeutic strategies. The occurrence of reactional episodes and relapse in leprosy patients, the emergence of resistant mycobacteria strains, and the absence of effective drugs to treat mycobacterial cutaneous infection increased the interest in the development of therapies based on repurposed drugs against mycobacteria. The mechanism of action of many of these therapies evaluated is linked to the activation of autophagy. Autophagy is an evolutionary conserved lysosomal degradation pathway that has been associated with the control of the mycobacterial bacillary load. Here, we review the role of autophagy in the pathogenesis of cutaneous mycobacterial infection and discuss the perspectives of autophagy as a target for drug development and repurposing against cutaneous mycobacterial infection.https://www.frontiersin.org/articles/10.3389/fimmu.2021.674241/fullautophagyskinmycobacteriadrug developmentskin cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tamiris Lameira Bittencourt Rhana Berto da Silva Prata Bruno Jorge de Andrade Silva Mayara Garcia de Mattos Barbosa Margareth Pretti Dalcolmo Roberta Olmo Pinheiro |
spellingShingle |
Tamiris Lameira Bittencourt Rhana Berto da Silva Prata Bruno Jorge de Andrade Silva Mayara Garcia de Mattos Barbosa Margareth Pretti Dalcolmo Roberta Olmo Pinheiro Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria Frontiers in Immunology autophagy skin mycobacteria drug development skin cells |
author_facet |
Tamiris Lameira Bittencourt Rhana Berto da Silva Prata Bruno Jorge de Andrade Silva Mayara Garcia de Mattos Barbosa Margareth Pretti Dalcolmo Roberta Olmo Pinheiro |
author_sort |
Tamiris Lameira Bittencourt |
title |
Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria |
title_short |
Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria |
title_full |
Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria |
title_fullStr |
Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria |
title_full_unstemmed |
Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria |
title_sort |
autophagy as a target for drug development of skin infection caused by mycobacteria |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2021-05-01 |
description |
Pathogenic mycobacteria species may subvert the innate immune mechanisms and can modulate the activation of cells that cause disease in the skin. Cutaneous mycobacterial infection may present different clinical presentations and it is associated with stigma, deformity, and disability. The understanding of the immunopathogenic mechanisms related to mycobacterial infection in human skin is of pivotal importance to identify targets for new therapeutic strategies. The occurrence of reactional episodes and relapse in leprosy patients, the emergence of resistant mycobacteria strains, and the absence of effective drugs to treat mycobacterial cutaneous infection increased the interest in the development of therapies based on repurposed drugs against mycobacteria. The mechanism of action of many of these therapies evaluated is linked to the activation of autophagy. Autophagy is an evolutionary conserved lysosomal degradation pathway that has been associated with the control of the mycobacterial bacillary load. Here, we review the role of autophagy in the pathogenesis of cutaneous mycobacterial infection and discuss the perspectives of autophagy as a target for drug development and repurposing against cutaneous mycobacterial infection. |
topic |
autophagy skin mycobacteria drug development skin cells |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.674241/full |
work_keys_str_mv |
AT tamirislameirabittencourt autophagyasatargetfordrugdevelopmentofskininfectioncausedbymycobacteria AT rhanabertodasilvaprata autophagyasatargetfordrugdevelopmentofskininfectioncausedbymycobacteria AT brunojorgedeandradesilva autophagyasatargetfordrugdevelopmentofskininfectioncausedbymycobacteria AT mayaragarciademattosbarbosa autophagyasatargetfordrugdevelopmentofskininfectioncausedbymycobacteria AT margarethprettidalcolmo autophagyasatargetfordrugdevelopmentofskininfectioncausedbymycobacteria AT robertaolmopinheiro autophagyasatargetfordrugdevelopmentofskininfectioncausedbymycobacteria |
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1721427916569444352 |