TRIM32 and Malin in Neurological and Neuromuscular Rare Diseases

TRIM32 and Malin in Neurological and Neuromuscular Rare Diseases

Tripartite motif (TRIM) proteins are RING E3 ubiquitin ligases defined by a shared domain structure. Several of them are implicated in rare genetic diseases, and mutations in TRIM32 and TRIM-like malin are associated with Limb-Girdle Muscular Dystrophy R8 and Lafora disease, respectively. These two...

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Bibliographic Details
Main Authors: Lorena Kumarasinghe, Lu Xiong, Maria Adelaida Garcia-Gimeno, Elisa Lazzari, Pascual Sanz, Germana Meroni
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
TRIM proteins
E3-ligase
Trim32
malin
ubiquitination
Limb-Girdle Muscular Dystrophy
Online Access:https://www.mdpi.com/2073-4409/10/4/820

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