Role of apoptosis in the рathogenesis of glaucomatous optic nerve damage during primary open-angle glaucoma
<p>This work is devoted to the study of the molecular mechanisms of programmed cell death or apoptosis in primary open-angleglaucoma. As one of the main factors in the pathogenesis of this disease appears the loss of retinal ganglion cells. Their death occursby apoptosis — programmed suicide m...
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Ophthalmology Publishing Group
2014-07-01
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doaj-c81e2bb143bf46cab8bb1c24ee29d08c2020-11-24T22:39:28ZrusOphthalmology Publishing GroupOftalʹmologiâ 1816-50952014-07-01104510116Role of apoptosis in the рathogenesis of glaucomatous optic nerve damage during primary open-angle glaucomaM. A. Frolov0O. S. Slepova1N. S. Morozova2Dzh. N. Lovpache3A. M. Frolov4Российский Университет Дружбы НародовРоссийский Университет Дружбы НародовФГБУ «Московский НИИ глазных болезней им. Гельмгольца» МЗ РФРоссийский Университет Дружбы НародовФГБУ «Московский НИИ глазных болезней им. Гельмгольца» МЗ РФ<p>This work is devoted to the study of the molecular mechanisms of programmed cell death or apoptosis in primary open-angleglaucoma. As one of the main factors in the pathogenesis of this disease appears the loss of retinal ganglion cells. Their death occursby apoptosis — programmed suicide mechanism. We consider two major apoptotic pathways, which are described in the literature —Fas-mediated and Bcl-2-dependent or mitochondrial. The existence of these paths and their regulators in many organs and tissues isdescribed, including the retina and optic nerve. Based on the analysis of domestic and foreign literature is presented modern view ofthe stages of this process in glaucoma. A thorough understanding of the mechanisms of apoptosis and their regulation may contribute to the development of new pharmacological methods of prevention and treatment of eye diseases</p>http://www.ophthalmojournal.com/index.php/opht/article/view/116apoptosisprogrammed cell deathglaucomaoptic nerveretinaglaucomatous optic neuropathy |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
M. A. Frolov O. S. Slepova N. S. Morozova Dzh. N. Lovpache A. M. Frolov |
spellingShingle |
M. A. Frolov O. S. Slepova N. S. Morozova Dzh. N. Lovpache A. M. Frolov Role of apoptosis in the рathogenesis of glaucomatous optic nerve damage during primary open-angle glaucoma Oftalʹmologiâ apoptosis programmed cell death glaucoma optic nerve retina glaucomatous optic neuropathy |
author_facet |
M. A. Frolov O. S. Slepova N. S. Morozova Dzh. N. Lovpache A. M. Frolov |
author_sort |
M. A. Frolov |
title |
Role of apoptosis in the рathogenesis of glaucomatous optic nerve damage during primary open-angle glaucoma |
title_short |
Role of apoptosis in the рathogenesis of glaucomatous optic nerve damage during primary open-angle glaucoma |
title_full |
Role of apoptosis in the рathogenesis of glaucomatous optic nerve damage during primary open-angle glaucoma |
title_fullStr |
Role of apoptosis in the рathogenesis of glaucomatous optic nerve damage during primary open-angle glaucoma |
title_full_unstemmed |
Role of apoptosis in the рathogenesis of glaucomatous optic nerve damage during primary open-angle glaucoma |
title_sort |
role of apoptosis in the рathogenesis of glaucomatous optic nerve damage during primary open-angle glaucoma |
publisher |
Ophthalmology Publishing Group |
series |
Oftalʹmologiâ |
issn |
1816-5095 |
publishDate |
2014-07-01 |
description |
<p>This work is devoted to the study of the molecular mechanisms of programmed cell death or apoptosis in primary open-angleglaucoma. As one of the main factors in the pathogenesis of this disease appears the loss of retinal ganglion cells. Their death occursby apoptosis — programmed suicide mechanism. We consider two major apoptotic pathways, which are described in the literature —Fas-mediated and Bcl-2-dependent or mitochondrial. The existence of these paths and their regulators in many organs and tissues isdescribed, including the retina and optic nerve. Based on the analysis of domestic and foreign literature is presented modern view ofthe stages of this process in glaucoma. A thorough understanding of the mechanisms of apoptosis and their regulation may contribute to the development of new pharmacological methods of prevention and treatment of eye diseases</p> |
topic |
apoptosis programmed cell death glaucoma optic nerve retina glaucomatous optic neuropathy |
url |
http://www.ophthalmojournal.com/index.php/opht/article/view/116 |
work_keys_str_mv |
AT mafrolov roleofapoptosisintherathogenesisofglaucomatousopticnervedamageduringprimaryopenangleglaucoma AT osslepova roleofapoptosisintherathogenesisofglaucomatousopticnervedamageduringprimaryopenangleglaucoma AT nsmorozova roleofapoptosisintherathogenesisofglaucomatousopticnervedamageduringprimaryopenangleglaucoma AT dzhnlovpache roleofapoptosisintherathogenesisofglaucomatousopticnervedamageduringprimaryopenangleglaucoma AT amfrolov roleofapoptosisintherathogenesisofglaucomatousopticnervedamageduringprimaryopenangleglaucoma |
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1725708840224161792 |