Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer
Background: This study was designed to determine the frequency of Microsatellite Instability (MSI) in young Iranian patients with endometrial carcinoma and to evaluate its association with histopathologic and clinical features of disease. Methods: Microsatellite status was analyzed in 23 patients w...
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Tehran University of Medical Sciences
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doaj-c828e5f2cad4438492f6c8155ffe939f2020-12-02T18:52:32ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932009-09-01383Microsatellite Instability in Young Women with Endometrioid type Endometrial CancerMR Abbaszadegan0H Asadzadeh Aghdayi1F Rastin 2E Dadkhah3M Lotfalizadeh 4N Mohamadian Roshan5M Farzadnia6A Velayati7A A'rabi 8Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad UniversInternal Medicine Ward, Razavi Hospital, Mashhad, IranDept. of Obstetrics & Gynecology, Imam Reza Hospital, MUMS, Mashhad, IranDivision of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad Univers Background: This study was designed to determine the frequency of Microsatellite Instability (MSI) in young Iranian patients with endometrial carcinoma and to evaluate its association with histopathologic and clinical features of disease. Methods: Microsatellite status was analyzed in 23 patients with endometrioid type endometrial cancer who were less than 55 years. Clinicopathologic characteristics such as age, International Federation of Gynecology and Obstetric (FIGO) grading and staging of tumor, family history of Hereditary Non-polyposis Colorectal Cancer (HNPCC), oral conception (OC) consumption, number of pregnancies, fertility, menstrual cycles and underlying disease were considered. Chi-square and Fisher exact tests were used to find the significant relationships. Results: MSI analysis showed 8 patients (34.8%) were MSS (Microsatellite Stable), 15 patients (62.5%) were MSI positive. Among cases with MSI phenotype, 4 cases (17.4%) had low instability (MSI-L) and 11 cases (47.8%) had high instability (MSI-H). Three cases with MSI-H had family history of HNPCC related cancers. Five cases (21.7%) had infertility in which 4 of them (80%) had MSI phenotype. There was no statistically significant relationship between MSI phenotype and tumor grade and stage. Conclusion: Few studies reported high frequency of MSI among young patients. Some studies mentioned similar results in endometrioid type of tumor. This study showed even higher frequency (65%) when MSI analyzed in young endometrioid type endometrial patients. Most cases with infertility had MSI-H phenotype. It may suggest that beside women with family history of HNPCC, EC screening using MSI would be beneficial in infertile women too. https://ijph.tums.ac.ir/index.php/ijph/article/view/3167Microsatellite instabilityEndometrial CancerYoung patientsEndometrioidIran |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
MR Abbaszadegan H Asadzadeh Aghdayi F Rastin E Dadkhah M Lotfalizadeh N Mohamadian Roshan M Farzadnia A Velayati A A'rabi |
spellingShingle |
MR Abbaszadegan H Asadzadeh Aghdayi F Rastin E Dadkhah M Lotfalizadeh N Mohamadian Roshan M Farzadnia A Velayati A A'rabi Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer Iranian Journal of Public Health Microsatellite instability Endometrial Cancer Young patients Endometrioid Iran |
author_facet |
MR Abbaszadegan H Asadzadeh Aghdayi F Rastin E Dadkhah M Lotfalizadeh N Mohamadian Roshan M Farzadnia A Velayati A A'rabi |
author_sort |
MR Abbaszadegan |
title |
Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer |
title_short |
Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer |
title_full |
Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer |
title_fullStr |
Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer |
title_full_unstemmed |
Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer |
title_sort |
microsatellite instability in young women with endometrioid type endometrial cancer |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Public Health |
issn |
2251-6085 2251-6093 |
publishDate |
2009-09-01 |
description |
Background: This study was designed to determine the frequency of Microsatellite Instability (MSI) in young Iranian patients with endometrial carcinoma and to evaluate its association with histopathologic and clinical features of disease.
Methods: Microsatellite status was analyzed in 23 patients with endometrioid type endometrial cancer who were less than 55 years. Clinicopathologic characteristics such as age, International Federation of Gynecology and Obstetric (FIGO) grading and staging of tumor, family history of Hereditary Non-polyposis Colorectal Cancer (HNPCC), oral conception (OC) consumption, number of pregnancies, fertility, menstrual cycles and underlying disease were considered. Chi-square and Fisher exact tests were used to find the significant relationships.
Results: MSI analysis showed 8 patients (34.8%) were MSS (Microsatellite Stable), 15 patients (62.5%) were MSI positive. Among cases with MSI phenotype, 4 cases (17.4%) had low instability (MSI-L) and 11 cases (47.8%) had high instability (MSI-H). Three cases with MSI-H had family history of HNPCC related cancers. Five cases (21.7%) had infertility in which 4 of them (80%) had MSI phenotype. There was no statistically significant relationship between MSI phenotype and tumor grade and stage.
Conclusion: Few studies reported high frequency of MSI among young patients. Some studies mentioned similar results in endometrioid type of tumor. This study showed even higher frequency (65%) when MSI analyzed in young endometrioid type endometrial patients. Most cases with infertility had MSI-H phenotype. It may suggest that beside women with family history of HNPCC, EC screening using MSI would be beneficial in infertile women too.
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topic |
Microsatellite instability Endometrial Cancer Young patients Endometrioid Iran |
url |
https://ijph.tums.ac.ir/index.php/ijph/article/view/3167 |
work_keys_str_mv |
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1724402791653310464 |