Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer
Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alon...
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MDPI AG
2014-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/7/10090 |
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doaj-c8306100646d4f168884eaa4d1396ab62020-11-24T21:05:33ZengMDPI AGMolecules1420-30492014-07-01197100901010210.3390/molecules190710090molecules190710090Synthesis of a 2ꞌꞌ-Deoxy-β-GalCerMeena S. Thakur0Archana Khurana1Mitchell Kronenberg2Amy R. Howell3Department of Chemistry, University of Connecticut, 55 N. Eagleville Rd., Storrs, CT 06269, USALa Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USALa Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USADepartment of Chemistry, University of Connecticut, 55 N. Eagleville Rd., Storrs, CT 06269, USAStructural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2ꞌꞌ-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells.http://www.mdpi.com/1420-3049/19/7/10090β-GalCerantigensNKT cellsCD1d |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Meena S. Thakur Archana Khurana Mitchell Kronenberg Amy R. Howell |
| spellingShingle |
Meena S. Thakur Archana Khurana Mitchell Kronenberg Amy R. Howell Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer Molecules β-GalCer antigens NKT cells CD1d |
| author_facet |
Meena S. Thakur Archana Khurana Mitchell Kronenberg Amy R. Howell |
| author_sort |
Meena S. Thakur |
| title |
Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer |
| title_short |
Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer |
| title_full |
Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer |
| title_fullStr |
Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer |
| title_full_unstemmed |
Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer |
| title_sort |
synthesis of a 2ꞌꞌ-deoxy-β-galcer |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2014-07-01 |
| description |
Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2ꞌꞌ-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells. |
| topic |
β-GalCer antigens NKT cells CD1d |
| url |
http://www.mdpi.com/1420-3049/19/7/10090 |
| work_keys_str_mv |
AT meenasthakur synthesisofa2ꞌꞌdeoxybgalcer AT archanakhurana synthesisofa2ꞌꞌdeoxybgalcer AT mitchellkronenberg synthesisofa2ꞌꞌdeoxybgalcer AT amyrhowell synthesisofa2ꞌꞌdeoxybgalcer |
| _version_ |
1716768336894754816 |