Gender differences in pharmacokinetics and pharmacodynamics of methadone substitution therapy

Gender-related differences in the pharmacological effects of drug are an emerging topic. This review examines gender differences in both pharmacokinetic and pharmacodynamic aspects of methadone, a long-acting opioid agonist that is prescribed as a treatment for opioid dependence and the management o...

Full description

Bibliographic Details
Main Authors: Manuela eGraziani, Robert eNistico
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00122/full