Infection by Epstein–Barr virus in Fes (Morocco). Prevalence and predictors of positivity in nasopharyngeal cancer
Objectives: To determine the prevalence and genotypic distribution of Epstein–Barr virus (EBV) in a sample of patients of Hassan II University Hospital (Morocco) due to nasopharyngeal pathologies and requiring a biopsy. We identified factors associated to the EBV infection. Methods: 112 patients wer...
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doaj-c8396e6a21b443389ca1d1264fab2d602020-11-25T02:17:15ZengElsevierJournal of Infection and Public Health1876-03412018-11-01116807811Infection by Epstein–Barr virus in Fes (Morocco). Prevalence and predictors of positivity in nasopharyngeal cancerMehdi El-Amrani-Joutey0Rodrigo Jiménez-García1Rafael Linares-García-Valdecasas2María A. Palomar-Gallego3Isabel Jiménez-Trujillo4Ana López-de-Andrés5Luis Vázquez-Vázquez6Human Anatomy and Embryology Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Madrid, SpainPreventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Madrid, Spain; Corresponding author at: Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Avda. de Atenas s/n, 28922 Alcorcón, Madrid, Spain.Human Anatomy and Embryology Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Madrid, SpainHuman Anatomy and Embryology Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Madrid, SpainPreventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Madrid, SpainPreventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Madrid, SpainHuman Anatomy and Embryology Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Madrid, SpainObjectives: To determine the prevalence and genotypic distribution of Epstein–Barr virus (EBV) in a sample of patients of Hassan II University Hospital (Morocco) due to nasopharyngeal pathologies and requiring a biopsy. We identified factors associated to the EBV infection. Methods: 112 patients were recruited (January 2012–October 2014). Biopsies were conducted for the molecular diagnosis of EBV. The data collected included sociodemographic characteristics, smoking and drug abuse, medical background and histologic diagnosis. The EBV diagnosis was performed via the Polymerase Chain Reaction. Results: 50% of patients were infected by EBV (98.2% with EBV type A compared to 1.8% type B). Most infected patients were ≥40 years(65.5%), male (59.6%) and in unfavorable socioeconomic circumstances. 83.3% of patients with lymphoma and 69.8% of patients with nasopharyngeal carcinoma presented concomitant EBV infections. 88.9% of patients who took drugs were infected by EBV compared to 47.7% of those who did not. In the multivariate analysis, age (OR 1.03; IC95% 1.02–1.06), smoking (OR 4.28; IC95%1.24–14.78) and having a malignant process (OR 6.96; IC95% 2.26–21.44) were significantly associated with EBV. Conclusions: Infection by EBV is related to several factors, such as advanced age, smoking, and suffering a malignant process. In subjects with malignant pathologies, positivity to EBV seems to be inferior to that found in other countries. Keywords: Epstein–Barr virus, Epidemiology, Outcomes, Carcinomahttp://www.sciencedirect.com/science/article/pii/S187603411830073X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mehdi El-Amrani-Joutey Rodrigo Jiménez-García Rafael Linares-García-Valdecasas María A. Palomar-Gallego Isabel Jiménez-Trujillo Ana López-de-Andrés Luis Vázquez-Vázquez |
spellingShingle |
Mehdi El-Amrani-Joutey Rodrigo Jiménez-García Rafael Linares-García-Valdecasas María A. Palomar-Gallego Isabel Jiménez-Trujillo Ana López-de-Andrés Luis Vázquez-Vázquez Infection by Epstein–Barr virus in Fes (Morocco). Prevalence and predictors of positivity in nasopharyngeal cancer Journal of Infection and Public Health |
author_facet |
Mehdi El-Amrani-Joutey Rodrigo Jiménez-García Rafael Linares-García-Valdecasas María A. Palomar-Gallego Isabel Jiménez-Trujillo Ana López-de-Andrés Luis Vázquez-Vázquez |
author_sort |
Mehdi El-Amrani-Joutey |
title |
Infection by Epstein–Barr virus in Fes (Morocco). Prevalence and predictors of positivity in nasopharyngeal cancer |
title_short |
Infection by Epstein–Barr virus in Fes (Morocco). Prevalence and predictors of positivity in nasopharyngeal cancer |
title_full |
Infection by Epstein–Barr virus in Fes (Morocco). Prevalence and predictors of positivity in nasopharyngeal cancer |
title_fullStr |
Infection by Epstein–Barr virus in Fes (Morocco). Prevalence and predictors of positivity in nasopharyngeal cancer |
title_full_unstemmed |
Infection by Epstein–Barr virus in Fes (Morocco). Prevalence and predictors of positivity in nasopharyngeal cancer |
title_sort |
infection by epstein–barr virus in fes (morocco). prevalence and predictors of positivity in nasopharyngeal cancer |
publisher |
Elsevier |
series |
Journal of Infection and Public Health |
issn |
1876-0341 |
publishDate |
2018-11-01 |
description |
Objectives: To determine the prevalence and genotypic distribution of Epstein–Barr virus (EBV) in a sample of patients of Hassan II University Hospital (Morocco) due to nasopharyngeal pathologies and requiring a biopsy. We identified factors associated to the EBV infection. Methods: 112 patients were recruited (January 2012–October 2014). Biopsies were conducted for the molecular diagnosis of EBV. The data collected included sociodemographic characteristics, smoking and drug abuse, medical background and histologic diagnosis. The EBV diagnosis was performed via the Polymerase Chain Reaction. Results: 50% of patients were infected by EBV (98.2% with EBV type A compared to 1.8% type B). Most infected patients were ≥40 years(65.5%), male (59.6%) and in unfavorable socioeconomic circumstances. 83.3% of patients with lymphoma and 69.8% of patients with nasopharyngeal carcinoma presented concomitant EBV infections. 88.9% of patients who took drugs were infected by EBV compared to 47.7% of those who did not. In the multivariate analysis, age (OR 1.03; IC95% 1.02–1.06), smoking (OR 4.28; IC95%1.24–14.78) and having a malignant process (OR 6.96; IC95% 2.26–21.44) were significantly associated with EBV. Conclusions: Infection by EBV is related to several factors, such as advanced age, smoking, and suffering a malignant process. In subjects with malignant pathologies, positivity to EBV seems to be inferior to that found in other countries. Keywords: Epstein–Barr virus, Epidemiology, Outcomes, Carcinoma |
url |
http://www.sciencedirect.com/science/article/pii/S187603411830073X |
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