Metacognitive therapy versus exposure and response prevention for obsessive-compulsive disorder: study protocol for a randomized controlled trial

• Main Authors: Kim Melchior, Ingmar Franken, Mathijs Deen, Colin van der Heiden
• Format: Article
• Language: English
• Published: BMC 2019-05-01
• Series: Trials
• Subjects: Obsessive-compulsive disorder; Metacognitive therapy; Exposure and response prevention; Randomized controlled trial
• Online Access: http://link.springer.com/article/10.1186/s13063-019-3381-9

Abstract Background The recommended psychological treatment of choice for obsessive-compulsive disorder (OCD) is exposure with response prevention (ERP). However, recovery rates are relatively modest, so better treatments are needed. This superiority study aims to explore the relative efficacy of metacognitive therapy (MCT), a new form of cognitive therapy based on the metacognitive model of OCD. Design and method In a randomized controlled trial, we will compare MCT with ERP. One hundred patients diagnosed with OCD will be recruited in an outpatient mental health center in Rotterdam (the Netherlands). The primary outcome measure is OCD severity, measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Data are assessed at baseline, after treatment, and at 6 and 30 months follow-up. Discussion By comparing MCT with ERP we hope to provide an indication whether MCT is efficacious in the treatment of OCD and, if so, whether it has the potential to be more efficacious than the current “gold standard” psychological treatment for OCD, ERP. Trial registration Dutch Trial Register, NTR4855. Registered on 21 October 2014.