DIRECT AND NEAREST RESULTS OF BRACHYTHERAPY IN DOSE HYPOFRACTIONATION MODE AND SINGLE IRRADIATION IN STAGE I-II SKIN CANCER
The aim of the work was to shorten the duration of radiation treatment, reduce the frequency and severity of skin radiations and achieve a pronounced economic and cosmetic effect while maintaining the effectiveness of treatment by developing non-standard dose fractionation regimens for brachythe...
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Grodno State Medical University
2018-09-01
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Online Access: | http://journal-grsmu.by/index.php/ojs/article/view/2299/2099 |
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doaj-c8440107c6f146e3b5551f045ff54f1d2020-11-24T22:31:13ZbelGrodno State Medical University Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta2221-87852413-01092018-09-0116443543910.25298/2221-8785-2018-16-4-435-439DIRECT AND NEAREST RESULTS OF BRACHYTHERAPY IN DOSE HYPOFRACTIONATION MODE AND SINGLE IRRADIATION IN STAGE I-II SKIN CANCER Zhmakina E. D.0Krutilina N. I.1Ovchinnikov V. A.2Healthcare Institution “Grodno Regional Clinical Hospital”State Educational Institution “Belarusian Medical Academy of Postgraduate Education”Educational Institution “Grodno State Medical University”The aim of the work was to shorten the duration of radiation treatment, reduce the frequency and severity of skin radiations and achieve a pronounced economic and cosmetic effect while maintaining the effectiveness of treatment by developing non-standard dose fractionation regimens for brachytherapy of stage I-II skin cancer. Material and methods. The material of the study was the results of examination and treatment of 120 patients suffering from stage I-II skin cancer. The patients were divided into two groups: those with brachytherapy in the mode of dose hypofractionation and those with brachytherapy in a single exposure mode. Results. Based on the linear-quadratic model (LQ model) of cellular survival, the modes of dose hypofractionation and single irradiation for brachytherapy of stage I-II skin cancer were developed and introduced into clinical practice. Conclusions. The use of brachytherapy in the modes of dose hypofractionation and single exposure allowed us to shorten significantly the treatment time, reduce the frequency and severity of acute radiation reactions and late radiation damage to the skin, achieve complete resorption of the tumor in 100% of cases, provide a pronounced economic effect as well as obtain excellent and good cosmetic results.http://journal-grsmu.by/index.php/ojs/article/view/2299/2099radiobiological substantiationhypofractionationsingle irradiationbrachytherapyskin cancer |
collection |
DOAJ |
language |
Belarusian |
format |
Article |
sources |
DOAJ |
author |
Zhmakina E. D. Krutilina N. I. Ovchinnikov V. A. |
spellingShingle |
Zhmakina E. D. Krutilina N. I. Ovchinnikov V. A. DIRECT AND NEAREST RESULTS OF BRACHYTHERAPY IN DOSE HYPOFRACTIONATION MODE AND SINGLE IRRADIATION IN STAGE I-II SKIN CANCER Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta radiobiological substantiation hypofractionation single irradiation brachytherapy skin cancer |
author_facet |
Zhmakina E. D. Krutilina N. I. Ovchinnikov V. A. |
author_sort |
Zhmakina E. D. |
title |
DIRECT AND NEAREST RESULTS OF BRACHYTHERAPY IN DOSE HYPOFRACTIONATION MODE AND SINGLE IRRADIATION IN STAGE I-II SKIN CANCER |
title_short |
DIRECT AND NEAREST RESULTS OF BRACHYTHERAPY IN DOSE HYPOFRACTIONATION MODE AND SINGLE IRRADIATION IN STAGE I-II SKIN CANCER |
title_full |
DIRECT AND NEAREST RESULTS OF BRACHYTHERAPY IN DOSE HYPOFRACTIONATION MODE AND SINGLE IRRADIATION IN STAGE I-II SKIN CANCER |
title_fullStr |
DIRECT AND NEAREST RESULTS OF BRACHYTHERAPY IN DOSE HYPOFRACTIONATION MODE AND SINGLE IRRADIATION IN STAGE I-II SKIN CANCER |
title_full_unstemmed |
DIRECT AND NEAREST RESULTS OF BRACHYTHERAPY IN DOSE HYPOFRACTIONATION MODE AND SINGLE IRRADIATION IN STAGE I-II SKIN CANCER |
title_sort |
direct and nearest results of brachytherapy in dose hypofractionation mode and single irradiation in stage i-ii skin cancer |
publisher |
Grodno State Medical University |
series |
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
issn |
2221-8785 2413-0109 |
publishDate |
2018-09-01 |
description |
The aim of the work was to shorten the duration of radiation treatment, reduce the frequency and severity of skin
radiations and achieve a pronounced economic and cosmetic effect while maintaining the effectiveness of treatment by
developing non-standard dose fractionation regimens for brachytherapy of stage I-II skin cancer.
Material and methods. The material of the study was the results of examination and treatment of 120 patients
suffering from stage I-II skin cancer. The patients were divided into two groups: those with brachytherapy in the mode
of dose hypofractionation and those with brachytherapy in a single exposure mode.
Results. Based on the linear-quadratic model (LQ model) of cellular survival, the modes of dose hypofractionation
and single irradiation for brachytherapy of stage I-II skin cancer were developed and introduced into clinical practice.
Conclusions. The use of brachytherapy in the modes of dose hypofractionation and single exposure allowed us
to shorten significantly the treatment time, reduce the frequency and severity of acute radiation reactions and late
radiation damage to the skin, achieve complete resorption of the tumor in 100% of cases, provide a pronounced
economic effect as well as obtain excellent and good cosmetic results. |
topic |
radiobiological substantiation hypofractionation single irradiation brachytherapy skin cancer |
url |
http://journal-grsmu.by/index.php/ojs/article/view/2299/2099 |
work_keys_str_mv |
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