Mitochondrial dysfunction in myasthenia gravis: report of a case
The case of an 11-year-old boy with external ophtalmoparesia, tetraparesia and bilateral eyelid ptosis is reported. He was 7-years-old when first symptoms appeared. Anticholinesterasic drugs were used. He was submitted to muscle biopsy. The results of histochemistry analysis showed storage of granul...
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Academia Brasileira de Neurologia (ABNEURO)
1989-09-01
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Series: | Arquivos de Neuro-Psiquiatria |
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doaj-c860d72ad30d4ae0a11fdfa1c396920e2020-11-24T20:41:31ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42271989-09-0147335535810.1590/S0004-282X1989000300018S0004-282X1989000300018Mitochondrial dysfunction in myasthenia gravis: report of a casePaulo E. Marchiori0J. A. Levy1Mary S. Carvalho-Alegro E. S. Lusvarghi2Ana M. Tsanaclis3J. Lamartine de Assis4M. ScaffUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloThe case of an 11-year-old boy with external ophtalmoparesia, tetraparesia and bilateral eyelid ptosis is reported. He was 7-years-old when first symptoms appeared. Anticholinesterasic drugs were used. He was submitted to muscle biopsy. The results of histochemistry analysis showed storage of granulous material at the subsarcolemmal region of muscle fibers by SDH. Increase in the number of mitochondria with electron dense bodies was found at electron microscopy. Anticholinesterasic drugs administration was interrupted and consequently he got worse, and bouts of dyspnea occurred. Due to this worsening anticholinesterasic agents were reintroduced together with prednisone, and he improved. Due to clinical and histological expressions we think it is possible that morphological mitochondrial alterations may occur also in myasthenia gravis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1989000300018&lng=en&tlng=en |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paulo E. Marchiori J. A. Levy Mary S. Carvalho-Alegro E. S. Lusvarghi Ana M. Tsanaclis J. Lamartine de Assis M. Scaff |
spellingShingle |
Paulo E. Marchiori J. A. Levy Mary S. Carvalho-Alegro E. S. Lusvarghi Ana M. Tsanaclis J. Lamartine de Assis M. Scaff Mitochondrial dysfunction in myasthenia gravis: report of a case Arquivos de Neuro-Psiquiatria |
author_facet |
Paulo E. Marchiori J. A. Levy Mary S. Carvalho-Alegro E. S. Lusvarghi Ana M. Tsanaclis J. Lamartine de Assis M. Scaff |
author_sort |
Paulo E. Marchiori |
title |
Mitochondrial dysfunction in myasthenia gravis: report of a case |
title_short |
Mitochondrial dysfunction in myasthenia gravis: report of a case |
title_full |
Mitochondrial dysfunction in myasthenia gravis: report of a case |
title_fullStr |
Mitochondrial dysfunction in myasthenia gravis: report of a case |
title_full_unstemmed |
Mitochondrial dysfunction in myasthenia gravis: report of a case |
title_sort |
mitochondrial dysfunction in myasthenia gravis: report of a case |
publisher |
Academia Brasileira de Neurologia (ABNEURO) |
series |
Arquivos de Neuro-Psiquiatria |
issn |
1678-4227 |
publishDate |
1989-09-01 |
description |
The case of an 11-year-old boy with external ophtalmoparesia, tetraparesia and bilateral eyelid ptosis is reported. He was 7-years-old when first symptoms appeared. Anticholinesterasic drugs were used. He was submitted to muscle biopsy. The results of histochemistry analysis showed storage of granulous material at the subsarcolemmal region of muscle fibers by SDH. Increase in the number of mitochondria with electron dense bodies was found at electron microscopy. Anticholinesterasic drugs administration was interrupted and consequently he got worse, and bouts of dyspnea occurred. Due to this worsening anticholinesterasic agents were reintroduced together with prednisone, and he improved. Due to clinical and histological expressions we think it is possible that morphological mitochondrial alterations may occur also in myasthenia gravis. |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1989000300018&lng=en&tlng=en |
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