The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population
Food predilection is linked to variants in the hepatokine “Fibroblast Growth Factor-21” gene (FGF21); with rs838133 linked to the sweet tooth in Caucasians. The effect of FGF21 variants on food intake is still unclear in other populations. A cohort of 196 healthy Emirati subjects was investigated [a...
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doaj-c8653d81ac7e472dbe7cb0d6e99ecd7c2020-11-25T03:30:07ZengElsevierJournal of Advanced Research2090-12322020-07-0124485494The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati populationMaha Saber-Ayad0Sarah Hammoudeh1Hadia Radwan2Shaista Manzoor3Hussein Jabbar4Rahaf Wardeh5Ahmed Ashraf6Peter Habib7Alsamman M. Alsamman8Rifat Hamoudi9College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; College of Medicine, Cairo University, Cairo, Egypt; Corresponding author at: M27-191 College of Medicine, University of Sharjah, 27272 Sharjah, UAE.College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab EmiratesResearch Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; Clinical Nutrition and Dietetics Department, College of Health Sciences, University of Sharjah, Sharjah, United Arab EmiratesCollege of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab EmiratesCollege of Medicine, University of Sharjah, Sharjah, United Arab EmiratesCollege of Medicine, University of Sharjah, Sharjah, United Arab EmiratesCollege of Medicine, University of Sharjah, Sharjah, United Arab EmiratesInternational Center for Agricultural Research in the Dry Areas (ICARDA), Giza, EgyptGenome Mapping Department, Agricultural Genetic Engineering Research Institute (AGERI), Giza, EgyptCollege of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab EmiratesFood predilection is linked to variants in the hepatokine “Fibroblast Growth Factor-21” gene (FGF21); with rs838133 linked to the sweet tooth in Caucasians. The effect of FGF21 variants on food intake is still unclear in other populations. A cohort of 196 healthy Emirati subjects was investigated [age: 30.34 ± 9.75yrs (44.4% males)]. The FGF21 rs838133 and rs838145 were genotyped. The daily intake was calculated based on a 61-item food frequency questionnaire. Multivariate analysis was performed using in house R script that implements two-way unsupervised hierarchical clustering to detect the association of the studied single-nucleotide polymorphisms (SNPs) and related SNPs in linkage disequilibrium, using data from the 1000 genome project. Both SNPs were in Hardy-Weinberg Equilaribium (HWE). BMI positively correlated with age (p = 0.002), but not with caloric intake. Salt intake was significantly higher in subjects homozygous (A: rs838133) and (G:rs838145),(p = 0.03 and 0.01, respectively). An interaction was observed between both SNPs; significantly associated with high salt intake. Using publicly available data, both SNPs fall within a region transmitted in Iberians which has a profile closely similar to Caucasians, but far from Chinese population. In conclusion, the minor alleles of FGF21 rs838145 and rs838133 are associated with high salt intake in Emiratis and may suggest neuro-metabolic link to dietary preference across different populations.http://www.sciencedirect.com/science/article/pii/S209012322030103XSalt intakeFood intakeFGF21United Arab EmiratesFood Frequency Questionnaire (FFQ)Multiple correspondence analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maha Saber-Ayad Sarah Hammoudeh Hadia Radwan Shaista Manzoor Hussein Jabbar Rahaf Wardeh Ahmed Ashraf Peter Habib Alsamman M. Alsamman Rifat Hamoudi |
spellingShingle |
Maha Saber-Ayad Sarah Hammoudeh Hadia Radwan Shaista Manzoor Hussein Jabbar Rahaf Wardeh Ahmed Ashraf Peter Habib Alsamman M. Alsamman Rifat Hamoudi The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population Journal of Advanced Research Salt intake Food intake FGF21 United Arab Emirates Food Frequency Questionnaire (FFQ) Multiple correspondence analysis |
author_facet |
Maha Saber-Ayad Sarah Hammoudeh Hadia Radwan Shaista Manzoor Hussein Jabbar Rahaf Wardeh Ahmed Ashraf Peter Habib Alsamman M. Alsamman Rifat Hamoudi |
author_sort |
Maha Saber-Ayad |
title |
The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population |
title_short |
The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population |
title_full |
The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population |
title_fullStr |
The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population |
title_full_unstemmed |
The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population |
title_sort |
fgf-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the emirati population |
publisher |
Elsevier |
series |
Journal of Advanced Research |
issn |
2090-1232 |
publishDate |
2020-07-01 |
description |
Food predilection is linked to variants in the hepatokine “Fibroblast Growth Factor-21” gene (FGF21); with rs838133 linked to the sweet tooth in Caucasians. The effect of FGF21 variants on food intake is still unclear in other populations. A cohort of 196 healthy Emirati subjects was investigated [age: 30.34 ± 9.75yrs (44.4% males)]. The FGF21 rs838133 and rs838145 were genotyped. The daily intake was calculated based on a 61-item food frequency questionnaire. Multivariate analysis was performed using in house R script that implements two-way unsupervised hierarchical clustering to detect the association of the studied single-nucleotide polymorphisms (SNPs) and related SNPs in linkage disequilibrium, using data from the 1000 genome project. Both SNPs were in Hardy-Weinberg Equilaribium (HWE). BMI positively correlated with age (p = 0.002), but not with caloric intake. Salt intake was significantly higher in subjects homozygous (A: rs838133) and (G:rs838145),(p = 0.03 and 0.01, respectively). An interaction was observed between both SNPs; significantly associated with high salt intake. Using publicly available data, both SNPs fall within a region transmitted in Iberians which has a profile closely similar to Caucasians, but far from Chinese population. In conclusion, the minor alleles of FGF21 rs838145 and rs838133 are associated with high salt intake in Emiratis and may suggest neuro-metabolic link to dietary preference across different populations. |
topic |
Salt intake Food intake FGF21 United Arab Emirates Food Frequency Questionnaire (FFQ) Multiple correspondence analysis |
url |
http://www.sciencedirect.com/science/article/pii/S209012322030103X |
work_keys_str_mv |
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