Chirality at the Nanoparticle Surface: Functionalization and Applications
Chiral molecules, such as amino acids and carbohydrates, are the building blocks of nature. As a consequence, most natural supramolecular structures, such as enzymes and receptors, are able to distinguish among different orientations in space of functional groups, and enantiomers of chiral drugs usu...
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doaj-c86f520df1644a2f808d40757e39de7c2020-11-25T02:59:56ZengMDPI AGApplied Sciences2076-34172020-08-01105357535710.3390/app10155357Chirality at the Nanoparticle Surface: Functionalization and ApplicationsMuhammad Shajih Zafar0Andrea Ragusa1Department of Engineering for Innovation, University of Salento, via Monteroni, 73100 Lecce, ItalyCNR Nanotec, Institute of Nanotechnology, via Monteroni, 73100 Lecce, ItalyChiral molecules, such as amino acids and carbohydrates, are the building blocks of nature. As a consequence, most natural supramolecular structures, such as enzymes and receptors, are able to distinguish among different orientations in space of functional groups, and enantiomers of chiral drugs usually have different pharmacokinetic properties and physiological effects. In this regard, the ability to recognize a single enantiomer from a racemic mixture is of paramount importance. Alternatively, the capacity to synthetize preferentially one enantiomer over another through a catalytic process can eliminate (or at least simplify) the subsequent isolation of only one enantiomer. The advent of nanotechnology has led to noteworthy improvements in many fields, from material science to nanomedicine. Similarly, nanoparticles functionalized with chiral molecules have been exploited in several fields. In this review, we report the recent advances of the use of chiral nanoparticles grouped in four major areas, i.e., enantioselective recognition, asymmetric catalysis, biosensing, and biomedicine.https://www.mdpi.com/2076-3417/10/15/5357chiralityenantiomerschiral nanoparticlesupramolecular chemistryasymmetric catalysisenantioselective recognition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Muhammad Shajih Zafar Andrea Ragusa |
spellingShingle |
Muhammad Shajih Zafar Andrea Ragusa Chirality at the Nanoparticle Surface: Functionalization and Applications Applied Sciences chirality enantiomers chiral nanoparticle supramolecular chemistry asymmetric catalysis enantioselective recognition |
author_facet |
Muhammad Shajih Zafar Andrea Ragusa |
author_sort |
Muhammad Shajih Zafar |
title |
Chirality at the Nanoparticle Surface: Functionalization and Applications |
title_short |
Chirality at the Nanoparticle Surface: Functionalization and Applications |
title_full |
Chirality at the Nanoparticle Surface: Functionalization and Applications |
title_fullStr |
Chirality at the Nanoparticle Surface: Functionalization and Applications |
title_full_unstemmed |
Chirality at the Nanoparticle Surface: Functionalization and Applications |
title_sort |
chirality at the nanoparticle surface: functionalization and applications |
publisher |
MDPI AG |
series |
Applied Sciences |
issn |
2076-3417 |
publishDate |
2020-08-01 |
description |
Chiral molecules, such as amino acids and carbohydrates, are the building blocks of nature. As a consequence, most natural supramolecular structures, such as enzymes and receptors, are able to distinguish among different orientations in space of functional groups, and enantiomers of chiral drugs usually have different pharmacokinetic properties and physiological effects. In this regard, the ability to recognize a single enantiomer from a racemic mixture is of paramount importance. Alternatively, the capacity to synthetize preferentially one enantiomer over another through a catalytic process can eliminate (or at least simplify) the subsequent isolation of only one enantiomer. The advent of nanotechnology has led to noteworthy improvements in many fields, from material science to nanomedicine. Similarly, nanoparticles functionalized with chiral molecules have been exploited in several fields. In this review, we report the recent advances of the use of chiral nanoparticles grouped in four major areas, i.e., enantioselective recognition, asymmetric catalysis, biosensing, and biomedicine. |
topic |
chirality enantiomers chiral nanoparticle supramolecular chemistry asymmetric catalysis enantioselective recognition |
url |
https://www.mdpi.com/2076-3417/10/15/5357 |
work_keys_str_mv |
AT muhammadshajihzafar chiralityatthenanoparticlesurfacefunctionalizationandapplications AT andrearagusa chiralityatthenanoparticlesurfacefunctionalizationandapplications |
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1724700231405142016 |