Relationship between age and white matter integrity in children with phenylketonuria
Diffusion tensor imaging (DTI) has shown poorer microstructural white matter integrity in children with phenylketonuria (PKU), specifically decreases in mean diffusivity (MD), in comparison with healthy children. However, little research has been conducted to investigate the relationship between age...
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2016-06-01
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doaj-c87cc424a48845c4bd4d36b74152fa962020-11-24T21:04:47ZengElsevierMolecular Genetics and Metabolism Reports2214-42692016-06-017C454910.1016/j.ymgmr.2016.03.003Relationship between age and white matter integrity in children with phenylketonuriaErika Wesonga0Joshua S. Shimony1Jerrel Rutlin2Dorothy K. Grange3Desiree A. White4Department of Psychological & Brain Sciences, One Brookings Drive, Campus Box 1125, Washington University, St. Louis, MO 63130, USAMallinckrodt Institute of Radiology, Campus Box 8131, Washington University, St. Louis, MO 63110, USADepartment of Psychiatry, Campus Box 8134, Washington University, St. Louis, MO 63110, USADepartment of Pediatrics, Campus Box 8116, Washington University, St. Louis, MO 63110, USADepartment of Psychological & Brain Sciences, One Brookings Drive, Campus Box 1125, Washington University, St. Louis, MO 63130, USADiffusion tensor imaging (DTI) has shown poorer microstructural white matter integrity in children with phenylketonuria (PKU), specifically decreases in mean diffusivity (MD), in comparison with healthy children. However, little research has been conducted to investigate the relationship between age and white matter integrity in this population. The present study examined group differences in the relationship between age and MD across a range of brain regions in 31 children with early- and continuously-treated PKU and 51 healthy control children. Relationships among MD, age, and group were explored using hierarchical linear regression and Pearson correlation. Results indicated a stronger age-related decrease in MD for children with PKU in comparison with healthy children in 4 of the 10 brain regions examined, suggesting that the trajectory of white matter development is abnormal in children with PKU. Further research using longitudinal methodology is needed to fully elucidate our understanding of white matter development in children with PKU.http://www.sciencedirect.com/science/article/pii/S2214426916300155PhenylketonuriaBrainWhite matterDiffusion tensor imagingChildren |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Erika Wesonga Joshua S. Shimony Jerrel Rutlin Dorothy K. Grange Desiree A. White |
spellingShingle |
Erika Wesonga Joshua S. Shimony Jerrel Rutlin Dorothy K. Grange Desiree A. White Relationship between age and white matter integrity in children with phenylketonuria Molecular Genetics and Metabolism Reports Phenylketonuria Brain White matter Diffusion tensor imaging Children |
author_facet |
Erika Wesonga Joshua S. Shimony Jerrel Rutlin Dorothy K. Grange Desiree A. White |
author_sort |
Erika Wesonga |
title |
Relationship between age and white matter integrity in children with phenylketonuria |
title_short |
Relationship between age and white matter integrity in children with phenylketonuria |
title_full |
Relationship between age and white matter integrity in children with phenylketonuria |
title_fullStr |
Relationship between age and white matter integrity in children with phenylketonuria |
title_full_unstemmed |
Relationship between age and white matter integrity in children with phenylketonuria |
title_sort |
relationship between age and white matter integrity in children with phenylketonuria |
publisher |
Elsevier |
series |
Molecular Genetics and Metabolism Reports |
issn |
2214-4269 |
publishDate |
2016-06-01 |
description |
Diffusion tensor imaging (DTI) has shown poorer microstructural white matter integrity in children with phenylketonuria (PKU), specifically decreases in mean diffusivity (MD), in comparison with healthy children. However, little research has been conducted to investigate the relationship between age and white matter integrity in this population. The present study examined group differences in the relationship between age and MD across a range of brain regions in 31 children with early- and continuously-treated PKU and 51 healthy control children. Relationships among MD, age, and group were explored using hierarchical linear regression and Pearson correlation. Results indicated a stronger age-related decrease in MD for children with PKU in comparison with healthy children in 4 of the 10 brain regions examined, suggesting that the trajectory of white matter development is abnormal in children with PKU. Further research using longitudinal methodology is needed to fully elucidate our understanding of white matter development in children with PKU. |
topic |
Phenylketonuria Brain White matter Diffusion tensor imaging Children |
url |
http://www.sciencedirect.com/science/article/pii/S2214426916300155 |
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