Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan’s unique ecosystems against influenza viruses and paramyxoviruses
Abstract Background Commercially available antiviral drugs, when used in the treatment of viral infections, do not always result in success. This is an urgent problem currently that needs to be addressed because several viruses including influenza and paramyxoviruses are acquiring multi-drug resista...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-12-01
|
Series: | Virology Journal |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12985-019-1254-1 |
id |
doaj-c8891a37e4414554a72e0e322336f095 |
---|---|
record_format |
Article |
spelling |
doaj-c8891a37e4414554a72e0e322336f0952020-12-06T12:28:29ZengBMCVirology Journal1743-422X2019-12-0116111610.1186/s12985-019-1254-1Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan’s unique ecosystems against influenza viruses and paramyxovirusesVladimir Berezin0Diyora Abdukhakimova1Lyudmila Trenozhnikova2Andrey Bogoyavlenskiy3Aizhan Turmagambetova4Alpamys Issanov5Azliyati Azizan6Research and Production Center for Microbiology and VirologyNazarbayev University School of Medicine (NUSOM)Research and Production Center for Microbiology and VirologyResearch and Production Center for Microbiology and VirologyResearch and Production Center for Microbiology and VirologyNazarbayev University School of Medicine (NUSOM)Nazarbayev University School of Medicine (NUSOM)Abstract Background Commercially available antiviral drugs, when used in the treatment of viral infections, do not always result in success. This is an urgent problem currently that needs to be addressed because several viruses including influenza and paramyxoviruses are acquiring multi-drug resistance. A potential solution for this emerging issue is to create new antiviral drugs from available compounds of natural products. It is known that the majority of drugs have been developed using compounds derived from actinomycetes, which are naturally occurring gram-positive bacteria. The purpose of this study was to investigate the antiviral properties of extremophilic actinomycetes extracts from strains that were isolated from extreme environments in Kazakhstan. Methods Five strains of extremophilic actinomycetes isolated from the unique ecosystems of Kazakhstan were extracted and tested for antiviral activity against influenza viruses (strains H7N1, H5N3, H1N1 and H3N2) and paramyxoviruses (Sendai Virus and Newcastle Disease Virus). The antiviral activity of these selected extracts was tested by checking their effect on hemagglutination and neuraminidase activities of the studied viruses. Additionally, actinomycetes extracts were compared with commercially available antiviral drugs and some plant preparations that have been shown to exhibit antiviral properties. Results The main findings show that extracts from strains K-192, K-340, K-362, K-522 and K525 showed antiviral activities when tested using influenza viruses, Sendai Virus, and Newcastle Disease Virus. These activities were comparable to those shown by Rimantadine and Tamiflu drugs, and “Virospan” and “Flavovir” plant preparations. Conclusions We identified several extracts with antiviral activities against several strains of influenza viruses and paramyxoviruses. Our research findings can be applied towards characterization and development of new antiviral drugs from the active actinomycetes extracts.https://doi.org/10.1186/s12985-019-1254-1ExtremophilesActinomycetesAntiviral inhibitionHemagglutination activityNeuraminidase activityAntiviral drugs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vladimir Berezin Diyora Abdukhakimova Lyudmila Trenozhnikova Andrey Bogoyavlenskiy Aizhan Turmagambetova Alpamys Issanov Azliyati Azizan |
spellingShingle |
Vladimir Berezin Diyora Abdukhakimova Lyudmila Trenozhnikova Andrey Bogoyavlenskiy Aizhan Turmagambetova Alpamys Issanov Azliyati Azizan Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan’s unique ecosystems against influenza viruses and paramyxoviruses Virology Journal Extremophiles Actinomycetes Antiviral inhibition Hemagglutination activity Neuraminidase activity Antiviral drugs |
author_facet |
Vladimir Berezin Diyora Abdukhakimova Lyudmila Trenozhnikova Andrey Bogoyavlenskiy Aizhan Turmagambetova Alpamys Issanov Azliyati Azizan |
author_sort |
Vladimir Berezin |
title |
Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan’s unique ecosystems against influenza viruses and paramyxoviruses |
title_short |
Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan’s unique ecosystems against influenza viruses and paramyxoviruses |
title_full |
Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan’s unique ecosystems against influenza viruses and paramyxoviruses |
title_fullStr |
Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan’s unique ecosystems against influenza viruses and paramyxoviruses |
title_full_unstemmed |
Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan’s unique ecosystems against influenza viruses and paramyxoviruses |
title_sort |
antiviral activities of extremophilic actinomycetes extracts from kazakhstan’s unique ecosystems against influenza viruses and paramyxoviruses |
publisher |
BMC |
series |
Virology Journal |
issn |
1743-422X |
publishDate |
2019-12-01 |
description |
Abstract Background Commercially available antiviral drugs, when used in the treatment of viral infections, do not always result in success. This is an urgent problem currently that needs to be addressed because several viruses including influenza and paramyxoviruses are acquiring multi-drug resistance. A potential solution for this emerging issue is to create new antiviral drugs from available compounds of natural products. It is known that the majority of drugs have been developed using compounds derived from actinomycetes, which are naturally occurring gram-positive bacteria. The purpose of this study was to investigate the antiviral properties of extremophilic actinomycetes extracts from strains that were isolated from extreme environments in Kazakhstan. Methods Five strains of extremophilic actinomycetes isolated from the unique ecosystems of Kazakhstan were extracted and tested for antiviral activity against influenza viruses (strains H7N1, H5N3, H1N1 and H3N2) and paramyxoviruses (Sendai Virus and Newcastle Disease Virus). The antiviral activity of these selected extracts was tested by checking their effect on hemagglutination and neuraminidase activities of the studied viruses. Additionally, actinomycetes extracts were compared with commercially available antiviral drugs and some plant preparations that have been shown to exhibit antiviral properties. Results The main findings show that extracts from strains K-192, K-340, K-362, K-522 and K525 showed antiviral activities when tested using influenza viruses, Sendai Virus, and Newcastle Disease Virus. These activities were comparable to those shown by Rimantadine and Tamiflu drugs, and “Virospan” and “Flavovir” plant preparations. Conclusions We identified several extracts with antiviral activities against several strains of influenza viruses and paramyxoviruses. Our research findings can be applied towards characterization and development of new antiviral drugs from the active actinomycetes extracts. |
topic |
Extremophiles Actinomycetes Antiviral inhibition Hemagglutination activity Neuraminidase activity Antiviral drugs |
url |
https://doi.org/10.1186/s12985-019-1254-1 |
work_keys_str_mv |
AT vladimirberezin antiviralactivitiesofextremophilicactinomycetesextractsfromkazakhstansuniqueecosystemsagainstinfluenzavirusesandparamyxoviruses AT diyoraabdukhakimova antiviralactivitiesofextremophilicactinomycetesextractsfromkazakhstansuniqueecosystemsagainstinfluenzavirusesandparamyxoviruses AT lyudmilatrenozhnikova antiviralactivitiesofextremophilicactinomycetesextractsfromkazakhstansuniqueecosystemsagainstinfluenzavirusesandparamyxoviruses AT andreybogoyavlenskiy antiviralactivitiesofextremophilicactinomycetesextractsfromkazakhstansuniqueecosystemsagainstinfluenzavirusesandparamyxoviruses AT aizhanturmagambetova antiviralactivitiesofextremophilicactinomycetesextractsfromkazakhstansuniqueecosystemsagainstinfluenzavirusesandparamyxoviruses AT alpamysissanov antiviralactivitiesofextremophilicactinomycetesextractsfromkazakhstansuniqueecosystemsagainstinfluenzavirusesandparamyxoviruses AT azliyatiazizan antiviralactivitiesofextremophilicactinomycetesextractsfromkazakhstansuniqueecosystemsagainstinfluenzavirusesandparamyxoviruses |
_version_ |
1724398784863010816 |