Daam2 driven degradation of VHL promotes gliomagenesis

Daam2 driven degradation of VHL promotes gliomagenesis

Von Hippel-Landau (VHL) protein is a potent tumor suppressor regulating numerous pathways that drive cancer, but mutations in VHL are restricted to limited subsets of malignancies. Here we identified a novel mechanism for VHL suppression in tumors that do not have inactivating mutations. Using devel...

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Bibliographic Details
Main Authors: Wenyi Zhu, Saritha Krishna, Cristina Garcia, Chia-Ching John Lin, Bartley D Mitchell, Kenneth L Scott, Carrie A Mohila, Chad J Creighton, Seung-Hee Yoo, Hyun Kyoung Lee, Benjamin Deneen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
Cancer Biology
Human
Mouse
Online Access:https://elifesciences.org/articles/31926

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