The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a series of quality control events including ribosome rescue, degradation of the stalled nascent polypeptide, and targeting of the mRNA for decay (No Go Decay or NGD). Using a reverse genetic screen in yeast, we...

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Bibliographic Details
Main Authors: Karole N D'Orazio, Colin Chih-Chien Wu, Niladri Sinha, Raphael Loll-Krippleber, Grant W Brown, Rachel Green
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
No Go Decay
endonuclease
mRNA
ubiquitin
Online Access:https://elifesciences.org/articles/49117

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