Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

It is believed that the bulk of cerebrospinal fluid (CSF) drains through arachnoid projections from the subarachnoid space to the dural venous sinuses. Here the authors show that the major outflow pathway for CSF in mice are lymphatic vessels and that this drainage decreases as the mice age.

Bibliographic Details
Main Authors: Qiaoli Ma, Benjamin V. Ineichen, Michael Detmar, Steven T. Proulx
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01484-6
Description
Summary:It is believed that the bulk of cerebrospinal fluid (CSF) drains through arachnoid projections from the subarachnoid space to the dural venous sinuses. Here the authors show that the major outflow pathway for CSF in mice are lymphatic vessels and that this drainage decreases as the mice age.
ISSN:2041-1723

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