Effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats
Maturation and aging induce alterations in glucose and protein metabolism, which are responsible for insulin resistance and sarcopenia. In the present study, we examined the effects of long-term (16 weeks) ingestion of diets supplemented with tetrahydrocurcumin (THC) and/or branched-chain amino acid...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Japanese Society of Physical Fitness and Sports Medicine
2013-11-01
|
Series: | Journal of Physical Fitness and Sports Medicine |
Subjects: | |
Online Access: | https://www.jstage.jst.go.jp/article/jpfsm/2/4/2_509/_pdf/-char/en |
id |
doaj-c8a7e76490fb4ce08a763de7144f7915 |
---|---|
record_format |
Article |
spelling |
doaj-c8a7e76490fb4ce08a763de7144f79152021-05-31T02:24:23ZengJapanese Society of Physical Fitness and Sports MedicineJournal of Physical Fitness and Sports Medicine2186-81312186-81232013-11-012450951310.7600/jpfsm.2.509jpfsmEffects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature ratsMika Mochizuki0Hiroshi Takayanagi1Sanshiro Yamada2Toshihiko Osawa3Yasuyuki Kitaura4Yoshiharu Shimomura5Department of Health and Nutrition, Faculty of Psychological and Physical Science, Aichi Gakuin UniversityLaboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya UniversityLaboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya UniversityDepartment of Health and Nutrition, Faculty of Psychological and Physical Science, Aichi Gakuin UniversityLaboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya UniversityLaboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya UniversityMaturation and aging induce alterations in glucose and protein metabolism, which are responsible for insulin resistance and sarcopenia. In the present study, we examined the effects of long-term (16 weeks) ingestion of diets supplemented with tetrahydrocurcumin (THC) and/or branched-chain amino acids (BCAAs) on glucose tolerance and soleus muscle protein content in mature rats (28 weeks of age). Intraperitoneal glucose tolerance tests (IPGTTs) were performed at week 6 and week 12 during the experimental period. Glucose tolerance was not affected by 6-week supplementation with THC and/or BCAAs, but was improved by supplementation at 12 weeks. A synergistic effect of THC and BCAAs was not observed. The protein content of the soleus muscle was increased by long-term supplementation with BCAAs, but not THC. These results suggest that THC and BCAAs are potentially beneficial supplements to improving maturation (aging)-related metabolic deterioration.https://www.jstage.jst.go.jp/article/jpfsm/2/4/2_509/_pdf/-char/entetrahydrocurcuminbranched-chain amino acidsglucose tolerancesoleus muscle proteinmature rats |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mika Mochizuki Hiroshi Takayanagi Sanshiro Yamada Toshihiko Osawa Yasuyuki Kitaura Yoshiharu Shimomura |
spellingShingle |
Mika Mochizuki Hiroshi Takayanagi Sanshiro Yamada Toshihiko Osawa Yasuyuki Kitaura Yoshiharu Shimomura Effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats Journal of Physical Fitness and Sports Medicine tetrahydrocurcumin branched-chain amino acids glucose tolerance soleus muscle protein mature rats |
author_facet |
Mika Mochizuki Hiroshi Takayanagi Sanshiro Yamada Toshihiko Osawa Yasuyuki Kitaura Yoshiharu Shimomura |
author_sort |
Mika Mochizuki |
title |
Effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats |
title_short |
Effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats |
title_full |
Effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats |
title_fullStr |
Effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats |
title_full_unstemmed |
Effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats |
title_sort |
effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats |
publisher |
Japanese Society of Physical Fitness and Sports Medicine |
series |
Journal of Physical Fitness and Sports Medicine |
issn |
2186-8131 2186-8123 |
publishDate |
2013-11-01 |
description |
Maturation and aging induce alterations in glucose and protein metabolism, which are responsible for insulin resistance and sarcopenia. In the present study, we examined the effects of long-term (16 weeks) ingestion of diets supplemented with tetrahydrocurcumin (THC) and/or branched-chain amino acids (BCAAs) on glucose tolerance and soleus muscle protein content in mature rats (28 weeks of age). Intraperitoneal glucose tolerance tests (IPGTTs) were performed at week 6 and week 12 during the experimental period. Glucose tolerance was not affected by 6-week supplementation with THC and/or BCAAs, but was improved by supplementation at 12 weeks. A synergistic effect of THC and BCAAs was not observed. The protein content of the soleus muscle was increased by long-term supplementation with BCAAs, but not THC. These results suggest that THC and BCAAs are potentially beneficial supplements to improving maturation (aging)-related metabolic deterioration. |
topic |
tetrahydrocurcumin branched-chain amino acids glucose tolerance soleus muscle protein mature rats |
url |
https://www.jstage.jst.go.jp/article/jpfsm/2/4/2_509/_pdf/-char/en |
work_keys_str_mv |
AT mikamochizuki effectsoflongtermsupplementationwithtetrahydrocurcuminandbranchedchainaminoacidsonglucosetoleranceandmuscleproteincontentinmaturerats AT hiroshitakayanagi effectsoflongtermsupplementationwithtetrahydrocurcuminandbranchedchainaminoacidsonglucosetoleranceandmuscleproteincontentinmaturerats AT sanshiroyamada effectsoflongtermsupplementationwithtetrahydrocurcuminandbranchedchainaminoacidsonglucosetoleranceandmuscleproteincontentinmaturerats AT toshihikoosawa effectsoflongtermsupplementationwithtetrahydrocurcuminandbranchedchainaminoacidsonglucosetoleranceandmuscleproteincontentinmaturerats AT yasuyukikitaura effectsoflongtermsupplementationwithtetrahydrocurcuminandbranchedchainaminoacidsonglucosetoleranceandmuscleproteincontentinmaturerats AT yoshiharushimomura effectsoflongtermsupplementationwithtetrahydrocurcuminandbranchedchainaminoacidsonglucosetoleranceandmuscleproteincontentinmaturerats |
_version_ |
1721419532006850560 |