The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs

The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs

Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequency than mutations and may involve population-scale...

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Bibliographic Details
Main Authors: Amanda C. Sharko, Chang-Uk Lim, Martina S. J. McDermott, Chuck Hennes, Kingsavanh P. Philavong, Tiffanie Aiken, Victor V. Tatarskiy, Igor B. Roninson, Eugenia V. Broude
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
CDK8
CDK19
EGFR
gefitinib
erlotinib
cetuximab
Online Access:https://www.mdpi.com/2073-4409/10/1/144

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