The Relation between Serum Levels of Oxidants and Antioxidants with Asthma Severity

• Main Authors: Touraj Roshanzamir, Sahar Vahdat
• Format: Article
• Language: fas
• Published: Vesnu Publications 2011-04-01
• Series: مجله دانشکده پزشکی اصفهان
• Subjects: Asthma; Antioxidant; Superoxide dismutase; Catalase; Superoxide hydrogen
• Online Access: http://jims.mui.ac.ir/index.php/jims/article/view/890

Background: Asthma considered as an inflammatory disease and the role of systemic and local oxidative stress in the pathogenesis of the disease has been suggested. The imbalance between oxidants and antioxidants has a significant role in the creation and control of asthma symptoms. The aim of this research was to study the relation between serum levels of oxidants and antioxidants with the severity of asthma.  Methods: In this observational-analytic cross-sectional study, 59 known asthmatic patients were included. The severity of asthma as mild, moderate, and severe was determined in studied patients based on their medical history, clinical symptoms, and pulmonary function tests. Serum levels of hydrogen superoxide, specific activity of superoxide dismutase enzymes and catalase, and total capacity of antioxidant levels in serum samples were evaluated. Findings: Mild, moderate, and severe asthma was presented among 21 (35.6%), 22 (37.3%), and 16 (27.1%) patients. There was significant positive relationship between the severity of asthma and specific activity of superoxide dismutase (P = 0.04; r = 0.21), mean of serum superoxide hydrogen (P < 0.01; r = 0.23), and the total capacity of antioxidants (P < 0.01; r = 0.31). There was significant negative relationship between the severity of asthma and specific activity of plasma catalase (P = 0.01; r = 0.28). Conclusion: The findings of current study confirmed the role of oxidant/antioxidant balance in asthma severity. To determine the more precise mechanisms of these compounds on pulmonary disease, especially asthma, further interventional studies on the effect of balance modification of oxidant/antioxidant on the severity, control, and the molecular basis of the disease is needed.