A genetic cell context-dependent role for ZEB1 in lung cancer
ZEB1 is a driver of epithelial-to-mesenchymal transition that usually promotes lung cancer in the context of KRAS mutation. Here, the authors uncover a growth suppressive role for ZEB1 in EGFRmutant lung adenocarcinoma, thus elucidating the context dependent function of this protein.
Bibliographic Details
Main Authors: |
Ting Zhang,
Lixia Guo,
Chad J. Creighton,
Qiang Lu,
Don L. Gibbons,
Eunhee S. Yi,
Bo Deng,
Julian R. Molina,
Zhifu Sun,
Ping Yang,
Yanan Yang |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2016-07-01
|
Series: | Nature Communications
|
Online Access: | https://doi.org/10.1038/ncomms12231
|