A genetic cell context-dependent role for ZEB1 in lung cancer

A genetic cell context-dependent role for ZEB1 in lung cancer

ZEB1 is a driver of epithelial-to-mesenchymal transition that usually promotes lung cancer in the context of KRAS mutation. Here, the authors uncover a growth suppressive role for ZEB1 in EGFRmutant lung adenocarcinoma, thus elucidating the context dependent function of this protein.

Bibliographic Details
Main Authors: Ting Zhang, Lixia Guo, Chad J. Creighton, Qiang Lu, Don L. Gibbons, Eunhee S. Yi, Bo Deng, Julian R. Molina, Zhifu Sun, Ping Yang, Yanan Yang
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12231

Internet

https://doi.org/10.1038/ncomms12231

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