Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy
Abstract Neurodegenerative diseases are characterized by the accumulation of specific phosphorylated protein aggregates in the brain, such as hyperphosphorylated tau (hp-tau) in tauopathies and phosphorylated α-synuclein (p-αSyn) in α-synucleinopathies. The simultaneous accumulation of different pro...
Main Authors: | Yuta Takaichi, James K. Chambers, Hiroyuki Inoue, Yasuhisa Ano, Akihiko Takashima, Hiroyuki Nakayama, Kazuyuki Uchida |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-06-01
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Series: | Acta Neuropathologica Communications |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40478-020-00969-8 |
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