The synthesis and characterization of some novel 5-chloro-2-(substituted alkoxy)-N-phenylbenzamide derivatives
To obtain biologically active compounds, the synthesis of some new derivatives with an o-hydroxybenzamide structure was performed. The ethyl esters 4–6 were obtained by the reaction of 5-chloro-2-hydroxy-N-phenylbenzamide and chloro-substituted acid ethyl esters 1–3 in ethyl methyl ketone. The obtai...
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doaj-c8b2a17fc65b4168be7449e83ff7bdad2020-11-24T20:47:06ZengSerbian Chemical Society Journal of the Serbian Chemical Society0352-51392009-08-01748-9846855The synthesis and characterization of some novel 5-chloro-2-(substituted alkoxy)-N-phenylbenzamide derivativesIOANA M. C. IENAŞCUALFA X. LUPEAIULIANA M. POPESCUMIRABELA A. PĂDUREALINA D. ZAMFIRTo obtain biologically active compounds, the synthesis of some new derivatives with an o-hydroxybenzamide structure was performed. The ethyl esters 4–6 were obtained by the reaction of 5-chloro-2-hydroxy-N-phenylbenzamide and chloro-substituted acid ethyl esters 1–3 in ethyl methyl ketone. The obtained ethyl esters were condensed with hydrazine yielding the hydrazides 7–8. The hydrazones 11–14 were obtained by the reaction of the hydrazides and the chloro-substituted benzaldehydes 9–10. All the newly synthesized compounds were characterized by FTIR, 1H-NMR, 13C-NMR, MS and elemental analyses.http://www.shd.org.rs/JSCS/Vol74/No8/01_3881_4027.pdf5-chloro-2-(substituted alkoxy)-N-phenylbenzamide derivativesethyl estershydrazideshydrazonesO-substituted salicylanilides |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
IOANA M. C. IENAŞCU ALFA X. LUPEA IULIANA M. POPESCU MIRABELA A. PĂDURE ALINA D. ZAMFIR |
spellingShingle |
IOANA M. C. IENAŞCU ALFA X. LUPEA IULIANA M. POPESCU MIRABELA A. PĂDURE ALINA D. ZAMFIR The synthesis and characterization of some novel 5-chloro-2-(substituted alkoxy)-N-phenylbenzamide derivatives Journal of the Serbian Chemical Society 5-chloro-2-(substituted alkoxy)-N-phenylbenzamide derivatives ethyl esters hydrazides hydrazones O-substituted salicylanilides |
author_facet |
IOANA M. C. IENAŞCU ALFA X. LUPEA IULIANA M. POPESCU MIRABELA A. PĂDURE ALINA D. ZAMFIR |
author_sort |
IOANA M. C. IENAŞCU |
title |
The synthesis and characterization of some novel 5-chloro-2-(substituted alkoxy)-N-phenylbenzamide derivatives |
title_short |
The synthesis and characterization of some novel 5-chloro-2-(substituted alkoxy)-N-phenylbenzamide derivatives |
title_full |
The synthesis and characterization of some novel 5-chloro-2-(substituted alkoxy)-N-phenylbenzamide derivatives |
title_fullStr |
The synthesis and characterization of some novel 5-chloro-2-(substituted alkoxy)-N-phenylbenzamide derivatives |
title_full_unstemmed |
The synthesis and characterization of some novel 5-chloro-2-(substituted alkoxy)-N-phenylbenzamide derivatives |
title_sort |
synthesis and characterization of some novel 5-chloro-2-(substituted alkoxy)-n-phenylbenzamide derivatives |
publisher |
Serbian Chemical Society |
series |
Journal of the Serbian Chemical Society |
issn |
0352-5139 |
publishDate |
2009-08-01 |
description |
To obtain biologically active compounds, the synthesis of some new derivatives with an o-hydroxybenzamide structure was performed. The ethyl esters 4–6 were obtained by the reaction of 5-chloro-2-hydroxy-N-phenylbenzamide and chloro-substituted acid ethyl esters 1–3 in ethyl methyl ketone. The obtained ethyl esters were condensed with hydrazine yielding the hydrazides 7–8. The hydrazones 11–14 were obtained by the reaction of the hydrazides and the chloro-substituted benzaldehydes 9–10. All the newly synthesized compounds were characterized by FTIR, 1H-NMR, 13C-NMR, MS and elemental analyses. |
topic |
5-chloro-2-(substituted alkoxy)-N-phenylbenzamide derivatives ethyl esters hydrazides hydrazones O-substituted salicylanilides |
url |
http://www.shd.org.rs/JSCS/Vol74/No8/01_3881_4027.pdf |
work_keys_str_mv |
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