Plastic roles of pericytes in the blood–retinal barrier

Plastic roles of pericytes in the blood–retinal barrier

Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to VEGF-A-induced endothelial sensitization by reg...

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Main Authors: Do Young Park, Junyeop Lee, Jaeryung Kim, Kangsan Kim, Seonpyo Hong, Sangyeul Han, Yoshiaki Kubota, Hellmut G. Augustin, Lei Ding, Jin Woo Kim, Hail Kim, Yulong He, Ralf H. Adams, Gou Young Koh
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15296
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spelling doaj-c8b70a95fd88461dbf21669c1f36b7f12021-05-11T07:36:32ZengNature Publishing GroupNature Communications2041-17232017-05-018111610.1038/ncomms15296Plastic roles of pericytes in the blood–retinal barrierDo Young Park0Junyeop Lee1Jaeryung Kim2Kangsan Kim3Seonpyo Hong4Sangyeul Han5Yoshiaki Kubota6Hellmut G. Augustin7Lei Ding8Jin Woo Kim9Hail Kim10Yulong He11Ralf H. Adams12Gou Young Koh13Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Center for Vascular Research, Institute of Basic Science (IBS)Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Center for Vascular Research, Institute of Basic Science (IBS)The Laboratory of Vascular Biology, Keio UniversityDivision of Vascular Oncology and Metastasis, German Cancer Research Center, DKFZ-ZMBH AllianceDepartment of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia Stem Cell Initiative, Columbia University Medical CenterDepartment of Biological Sciences, KAISTGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow UniversityDepartment of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of MünsterGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to VEGF-A-induced endothelial sensitization by regulating the Tie2/FOXO1/Ang2 axis.https://doi.org/10.1038/ncomms15296
collection DOAJ
language English
format Article
sources DOAJ
author Do Young Park
Junyeop Lee
Jaeryung Kim
Kangsan Kim
Seonpyo Hong
Sangyeul Han
Yoshiaki Kubota
Hellmut G. Augustin
Lei Ding
Jin Woo Kim
Hail Kim
Yulong He
Ralf H. Adams
Gou Young Koh
spellingShingle Do Young Park
Junyeop Lee
Jaeryung Kim
Kangsan Kim
Seonpyo Hong
Sangyeul Han
Yoshiaki Kubota
Hellmut G. Augustin
Lei Ding
Jin Woo Kim
Hail Kim
Yulong He
Ralf H. Adams
Gou Young Koh
Plastic roles of pericytes in the blood–retinal barrier
Nature Communications
author_facet Do Young Park
Junyeop Lee
Jaeryung Kim
Kangsan Kim
Seonpyo Hong
Sangyeul Han
Yoshiaki Kubota
Hellmut G. Augustin
Lei Ding
Jin Woo Kim
Hail Kim
Yulong He
Ralf H. Adams
Gou Young Koh
author_sort Do Young Park
title Plastic roles of pericytes in the blood–retinal barrier
title_short Plastic roles of pericytes in the blood–retinal barrier
title_full Plastic roles of pericytes in the blood–retinal barrier
title_fullStr Plastic roles of pericytes in the blood–retinal barrier
title_full_unstemmed Plastic roles of pericytes in the blood–retinal barrier
title_sort plastic roles of pericytes in the blood–retinal barrier
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to VEGF-A-induced endothelial sensitization by regulating the Tie2/FOXO1/Ang2 axis.
url https://doi.org/10.1038/ncomms15296
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