Plastic roles of pericytes in the blood–retinal barrier
Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to VEGF-A-induced endothelial sensitization by reg...
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2017-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms15296 |
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doaj-c8b70a95fd88461dbf21669c1f36b7f12021-05-11T07:36:32ZengNature Publishing GroupNature Communications2041-17232017-05-018111610.1038/ncomms15296Plastic roles of pericytes in the blood–retinal barrierDo Young Park0Junyeop Lee1Jaeryung Kim2Kangsan Kim3Seonpyo Hong4Sangyeul Han5Yoshiaki Kubota6Hellmut G. Augustin7Lei Ding8Jin Woo Kim9Hail Kim10Yulong He11Ralf H. Adams12Gou Young Koh13Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Center for Vascular Research, Institute of Basic Science (IBS)Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Center for Vascular Research, Institute of Basic Science (IBS)The Laboratory of Vascular Biology, Keio UniversityDivision of Vascular Oncology and Metastasis, German Cancer Research Center, DKFZ-ZMBH AllianceDepartment of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia Stem Cell Initiative, Columbia University Medical CenterDepartment of Biological Sciences, KAISTGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow UniversityDepartment of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of MünsterGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to VEGF-A-induced endothelial sensitization by regulating the Tie2/FOXO1/Ang2 axis.https://doi.org/10.1038/ncomms15296 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Do Young Park Junyeop Lee Jaeryung Kim Kangsan Kim Seonpyo Hong Sangyeul Han Yoshiaki Kubota Hellmut G. Augustin Lei Ding Jin Woo Kim Hail Kim Yulong He Ralf H. Adams Gou Young Koh |
spellingShingle |
Do Young Park Junyeop Lee Jaeryung Kim Kangsan Kim Seonpyo Hong Sangyeul Han Yoshiaki Kubota Hellmut G. Augustin Lei Ding Jin Woo Kim Hail Kim Yulong He Ralf H. Adams Gou Young Koh Plastic roles of pericytes in the blood–retinal barrier Nature Communications |
author_facet |
Do Young Park Junyeop Lee Jaeryung Kim Kangsan Kim Seonpyo Hong Sangyeul Han Yoshiaki Kubota Hellmut G. Augustin Lei Ding Jin Woo Kim Hail Kim Yulong He Ralf H. Adams Gou Young Koh |
author_sort |
Do Young Park |
title |
Plastic roles of pericytes in the blood–retinal barrier |
title_short |
Plastic roles of pericytes in the blood–retinal barrier |
title_full |
Plastic roles of pericytes in the blood–retinal barrier |
title_fullStr |
Plastic roles of pericytes in the blood–retinal barrier |
title_full_unstemmed |
Plastic roles of pericytes in the blood–retinal barrier |
title_sort |
plastic roles of pericytes in the blood–retinal barrier |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-05-01 |
description |
Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to VEGF-A-induced endothelial sensitization by regulating the Tie2/FOXO1/Ang2 axis. |
url |
https://doi.org/10.1038/ncomms15296 |
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