Amnestic mild cognitive impairment in Parkinson's disease: White matter structural changes and mechanisms.
Mild cognitive impairment (MCI) is a heterogeneous cognitive disorder that is often comorbid with Parkinson's diseases (PD). The amnestic subtype of PD-MCI (PD-aMCI) has a higher risk to develop dementia. However, there is a lack of studies on the white matter (WM) structural changes of PD-aMCI...
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doaj-c8b80bd13f194714bb76f15bb9384b0b2021-03-03T21:18:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-011412e022617510.1371/journal.pone.0226175Amnestic mild cognitive impairment in Parkinson's disease: White matter structural changes and mechanisms.Fuyong ChenTao WuYuejia LuoZhihao LiQing GuanXianghong MengWei TaoHaobo ZhangMild cognitive impairment (MCI) is a heterogeneous cognitive disorder that is often comorbid with Parkinson's diseases (PD). The amnestic subtype of PD-MCI (PD-aMCI) has a higher risk to develop dementia. However, there is a lack of studies on the white matter (WM) structural changes of PD-aMCI. We characterized the WM structural changes of PD-aMCI (n = 17) with cognitively normal PD (PD-CN, n = 19) and normal controls (n = 20), using voxel-based and tract-based spatial statistics (TBSS) analyses on fractional anisotropy (FA) axial diffusivity (AD), and radial diffusivity (RD). By excluding and then including the motor performance as a covariate in the comparison analysis between PD-aMCI and PD-CN, we attempted to discern the influences of two neuropathological mechanisms on the WM structural changes of PD-aMCI. The correlation analyses between memory and voxel-based WM measures in all PD patients were also performed (n = 36). The results showed that PD-aMCI had smaller FA values than PD-CN in the diffuse WM areas, and PD-CN had higher AD and RD values than normal controls in the right caudate. Most FA difference between PD-aMCI and PD-CN could be weakened by the motor adjustment. The FA differences between PD-aMCI and PD-CN were largely spatially overlapped with the memory-correlated FA values. Our findings demonstrated that the WM structural differences between PD-aMCI and PD-CN were mainly memory-related, and the influence of motor adjustment might indicate a common mechanism underlying both motor and memory impairment in PD-aMCI, possibly reflecting a predominant influence of dopaminergic neuropathology.https://doi.org/10.1371/journal.pone.0226175 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fuyong Chen Tao Wu Yuejia Luo Zhihao Li Qing Guan Xianghong Meng Wei Tao Haobo Zhang |
spellingShingle |
Fuyong Chen Tao Wu Yuejia Luo Zhihao Li Qing Guan Xianghong Meng Wei Tao Haobo Zhang Amnestic mild cognitive impairment in Parkinson's disease: White matter structural changes and mechanisms. PLoS ONE |
author_facet |
Fuyong Chen Tao Wu Yuejia Luo Zhihao Li Qing Guan Xianghong Meng Wei Tao Haobo Zhang |
author_sort |
Fuyong Chen |
title |
Amnestic mild cognitive impairment in Parkinson's disease: White matter structural changes and mechanisms. |
title_short |
Amnestic mild cognitive impairment in Parkinson's disease: White matter structural changes and mechanisms. |
title_full |
Amnestic mild cognitive impairment in Parkinson's disease: White matter structural changes and mechanisms. |
title_fullStr |
Amnestic mild cognitive impairment in Parkinson's disease: White matter structural changes and mechanisms. |
title_full_unstemmed |
Amnestic mild cognitive impairment in Parkinson's disease: White matter structural changes and mechanisms. |
title_sort |
amnestic mild cognitive impairment in parkinson's disease: white matter structural changes and mechanisms. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2019-01-01 |
description |
Mild cognitive impairment (MCI) is a heterogeneous cognitive disorder that is often comorbid with Parkinson's diseases (PD). The amnestic subtype of PD-MCI (PD-aMCI) has a higher risk to develop dementia. However, there is a lack of studies on the white matter (WM) structural changes of PD-aMCI. We characterized the WM structural changes of PD-aMCI (n = 17) with cognitively normal PD (PD-CN, n = 19) and normal controls (n = 20), using voxel-based and tract-based spatial statistics (TBSS) analyses on fractional anisotropy (FA) axial diffusivity (AD), and radial diffusivity (RD). By excluding and then including the motor performance as a covariate in the comparison analysis between PD-aMCI and PD-CN, we attempted to discern the influences of two neuropathological mechanisms on the WM structural changes of PD-aMCI. The correlation analyses between memory and voxel-based WM measures in all PD patients were also performed (n = 36). The results showed that PD-aMCI had smaller FA values than PD-CN in the diffuse WM areas, and PD-CN had higher AD and RD values than normal controls in the right caudate. Most FA difference between PD-aMCI and PD-CN could be weakened by the motor adjustment. The FA differences between PD-aMCI and PD-CN were largely spatially overlapped with the memory-correlated FA values. Our findings demonstrated that the WM structural differences between PD-aMCI and PD-CN were mainly memory-related, and the influence of motor adjustment might indicate a common mechanism underlying both motor and memory impairment in PD-aMCI, possibly reflecting a predominant influence of dopaminergic neuropathology. |
url |
https://doi.org/10.1371/journal.pone.0226175 |
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