CSF1R ⁃ related leukoencephalopathy: from hereditary diffuse leukoencephalopathy with spheroids to primary microgliopathy
Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare autosomal dominant hereditary leukoencephalopathy. Progressive neuropsychiatric symptoms and motor disorders are the main clinical manifestations, and women appear earlier than men. In imaging, diffusing white matter damage, thin...
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Tianjin Huanhu Hospital
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doaj-c8bb4332cb0f472fa11755f326b09d1e2020-11-25T01:02:32ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312020-01-0120122282033CSF1R ⁃ related leukoencephalopathy: from hereditary diffuse leukoencephalopathy with spheroids to primary microgliopathyYan⁃qiu WEIJun XURuo⁃xi LIULin LIZhen DONGHereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare autosomal dominant hereditary leukoencephalopathy. Progressive neuropsychiatric symptoms and motor disorders are the main clinical manifestations, and women appear earlier than men. In imaging, diffusing white matter damage, thinning of the corpus callosum and brain calcification are characteristic changes. Primary axonal degeneration and absence of myelin sheath are characteristic histopathological changes. Colony stimulating factor 1 receptor (CSF1R) is the only pathogenic gene of HDLS currently. Since CSF1R is mainly expressed in microglia, CSF1R⁃related leukoencephalopathy can be regarded as a representative of primary microgliopathy, and microglia play a key role in the pathogenesis of this disease. In this review, we discuss the current progress of CSF1R⁃related leukoencephalopathy, and reveal the possible pathophysiological role of microglia, as well as future research directions. DOI:10.3969/j.issn.1672⁃6731.2020.01.005http://www.cjcnn.org/index.php/cjcnn/article/view/2078leukoencephalopathiesreceptor, macrophage colony-stimulating factormicrogliareview |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan⁃qiu WEI Jun XU Ruo⁃xi LIU Lin LI Zhen DONG |
spellingShingle |
Yan⁃qiu WEI Jun XU Ruo⁃xi LIU Lin LI Zhen DONG CSF1R ⁃ related leukoencephalopathy: from hereditary diffuse leukoencephalopathy with spheroids to primary microgliopathy Chinese Journal of Contemporary Neurology and Neurosurgery leukoencephalopathies receptor, macrophage colony-stimulating factor microglia review |
author_facet |
Yan⁃qiu WEI Jun XU Ruo⁃xi LIU Lin LI Zhen DONG |
author_sort |
Yan⁃qiu WEI |
title |
CSF1R ⁃ related leukoencephalopathy: from hereditary diffuse leukoencephalopathy with spheroids to primary microgliopathy |
title_short |
CSF1R ⁃ related leukoencephalopathy: from hereditary diffuse leukoencephalopathy with spheroids to primary microgliopathy |
title_full |
CSF1R ⁃ related leukoencephalopathy: from hereditary diffuse leukoencephalopathy with spheroids to primary microgliopathy |
title_fullStr |
CSF1R ⁃ related leukoencephalopathy: from hereditary diffuse leukoencephalopathy with spheroids to primary microgliopathy |
title_full_unstemmed |
CSF1R ⁃ related leukoencephalopathy: from hereditary diffuse leukoencephalopathy with spheroids to primary microgliopathy |
title_sort |
csf1r ⁃ related leukoencephalopathy: from hereditary diffuse leukoencephalopathy with spheroids to primary microgliopathy |
publisher |
Tianjin Huanhu Hospital |
series |
Chinese Journal of Contemporary Neurology and Neurosurgery |
issn |
1672-6731 |
publishDate |
2020-01-01 |
description |
Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare autosomal dominant hereditary leukoencephalopathy. Progressive neuropsychiatric symptoms and motor disorders are the main clinical manifestations, and women appear earlier than men. In imaging, diffusing white matter damage, thinning of the corpus callosum and brain calcification are characteristic changes. Primary axonal degeneration and absence of myelin sheath are characteristic histopathological changes. Colony stimulating factor 1 receptor (CSF1R) is the only pathogenic gene of HDLS currently. Since CSF1R is mainly expressed in microglia, CSF1R⁃related leukoencephalopathy can be regarded as a representative of primary microgliopathy, and microglia play a key role in the pathogenesis of this disease. In this review, we discuss the current progress of CSF1R⁃related leukoencephalopathy, and reveal the possible pathophysiological role of microglia, as well as future research directions.
DOI:10.3969/j.issn.1672⁃6731.2020.01.005 |
topic |
leukoencephalopathies receptor, macrophage colony-stimulating factor microglia review |
url |
http://www.cjcnn.org/index.php/cjcnn/article/view/2078 |
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