Polyelectrolyte Complexes between Polycarboxylates and BMP-2 for Enhancing Osteogenic Differentiation: Effect of Chemical Structure of Polycarboxylates

Polyelectrolyte Complexes between Polycarboxylates and BMP-2 for Enhancing Osteogenic Differentiation: Effect of Chemical Structure of Polycarboxylates

Bone morphogenetic protein 2 (BMP-2) has received considerable attention because of its osteoinductivity, but its use is limited owing to its instability and adverse effects. To reduce the dose of BMP-2, complexation with heparin is a promising approach, because heparin enhances the osteoinductivity...

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Bibliographic Details
Main Authors: Masahiko Terauchi, Atsushi Tamura, Asato Tonegawa, Satoshi Yamaguchi, Tetsuya Yoda, Nobuhiko Yui
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Polymers
Subjects:
bone morphogenetic protein-2
osteogenic differentiation
polyelectrolyte complex
polycarboxylate
poly(glutamic acid)
Online Access:https://www.mdpi.com/2073-4360/11/8/1327

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