Effect of hypertrophy on left ventricular diastolic function in patients with hypertrophic cardiomyopathy
Background. Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric LV hypertrophy (LVH) and impairment in diastolic function. We assess the relationship between LVH and invasive indexes of diastolic function. Methods. 21 HCM patients underwent cardiac catheterization to assess pulmonary ca...
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doaj-c8de65b0d9ff4ce6acd10515792916d42020-11-24T21:35:58ZengTouch Medical MediaHeart International1826-18682036-25792006-09-012210.4081/hi.2006.106Effect of hypertrophy on left ventricular diastolic function in patients with hypertrophic cardiomyopathyMassimo ChiarielloBruno VillariRaffaella LombardiMaria Angela LosiSandro BetocchiQuirino CiampiBackground. Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric LV hypertrophy (LVH) and impairment in diastolic function. We assess the relationship between LVH and invasive indexes of diastolic function. Methods. 21 HCM patients underwent cardiac catheterization to assess pulmonary capillary wedge pressure, LV end-diastolic pressure (measured by microtip catheters), and LV volumes (calculated by simultaneous radionuclide angiography). We calculated from LV pressure the time constant of isovolumetric relaxation (τ, variable asymptote method, ms), and from LV pressure and volume the constant of chamber stiffness (k, ml-1). LVH was assessed by different indexes: maximal wall thickness, number of hypertrophied LV segments, LVH index, and Wigle’s score. Results. Wigle’s score was directly related to pulmonary capillary Wedge pressure (r=0.436, p=0.048), peak V wave of pulmonary capillary wedge pressure (r=0.503, p=0.024), LV end-diastolic pressure (r=0.643, p=0.002) and k (r=0.564, p=0.015). HCM patients were divided into 2 groups according to Wigle’s score: 10 with mild or moderate LVH (< 8), and 11 with severe LVH (≥ 8). HCM patients with severe LVH showed a higher pulmonary capillary Wedge pressure (15.1±7.2 vs 9.5±2.4, p=0.033), peak V wave of pulmonary capillary wedge pressure (20.7±4.6 vs 14.6±4.9, p=0.011), LV end-diastolic pressure (23.9±10.9 vs 10.6±2.5, p=0.002), k (0.0465±0.032 vs 0.015±0.007, p=0.022) and LV outflow tract gradient (72±36 mmHg vs 29±30 mmHg, p=0.01). τ was similar in the two groups. Other indexes of LVH were not related to diastolic function. Conclusions. Wigle’s score is the only index of LVH that relates to invasive indices of diastolic function.http://www.pagepress.org/journals/index.php/hi/article/view/1891Cardiomyopathy, Diastole, Hypertrophy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Massimo Chiariello Bruno Villari Raffaella Lombardi Maria Angela Losi Sandro Betocchi Quirino Ciampi |
spellingShingle |
Massimo Chiariello Bruno Villari Raffaella Lombardi Maria Angela Losi Sandro Betocchi Quirino Ciampi Effect of hypertrophy on left ventricular diastolic function in patients with hypertrophic cardiomyopathy Heart International Cardiomyopathy, Diastole, Hypertrophy |
author_facet |
Massimo Chiariello Bruno Villari Raffaella Lombardi Maria Angela Losi Sandro Betocchi Quirino Ciampi |
author_sort |
Massimo Chiariello |
title |
Effect of hypertrophy on left ventricular diastolic function in patients with hypertrophic cardiomyopathy |
title_short |
Effect of hypertrophy on left ventricular diastolic function in patients with hypertrophic cardiomyopathy |
title_full |
Effect of hypertrophy on left ventricular diastolic function in patients with hypertrophic cardiomyopathy |
title_fullStr |
Effect of hypertrophy on left ventricular diastolic function in patients with hypertrophic cardiomyopathy |
title_full_unstemmed |
Effect of hypertrophy on left ventricular diastolic function in patients with hypertrophic cardiomyopathy |
title_sort |
effect of hypertrophy on left ventricular diastolic function in patients with hypertrophic cardiomyopathy |
publisher |
Touch Medical Media |
series |
Heart International |
issn |
1826-1868 2036-2579 |
publishDate |
2006-09-01 |
description |
Background. Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric LV hypertrophy (LVH) and impairment in diastolic function. We assess the relationship between LVH and invasive indexes of diastolic function. Methods. 21 HCM patients underwent cardiac catheterization to assess pulmonary capillary wedge pressure, LV end-diastolic pressure (measured by microtip catheters), and LV volumes (calculated by simultaneous radionuclide angiography). We calculated from LV pressure the time constant of isovolumetric relaxation (τ, variable asymptote method, ms), and from LV pressure and volume the constant of chamber stiffness (k, ml-1). LVH was assessed by different indexes: maximal wall thickness, number of hypertrophied LV segments, LVH index, and Wigle’s score. Results. Wigle’s score was directly related to pulmonary capillary Wedge pressure (r=0.436, p=0.048), peak V wave of pulmonary capillary wedge pressure (r=0.503, p=0.024), LV end-diastolic pressure (r=0.643, p=0.002) and k (r=0.564, p=0.015). HCM patients were divided into 2 groups according to Wigle’s score: 10 with mild or moderate LVH (< 8), and 11 with severe LVH (≥ 8). HCM patients with severe LVH showed a higher pulmonary capillary Wedge pressure (15.1±7.2 vs 9.5±2.4, p=0.033), peak V wave of pulmonary capillary wedge pressure (20.7±4.6 vs 14.6±4.9, p=0.011), LV end-diastolic pressure (23.9±10.9 vs 10.6±2.5, p=0.002), k (0.0465±0.032 vs 0.015±0.007, p=0.022) and LV outflow tract gradient (72±36 mmHg vs 29±30 mmHg, p=0.01). τ was similar in the two groups. Other indexes of LVH were not related to diastolic function. Conclusions. Wigle’s score is the only index of LVH that relates to invasive indices of diastolic function. |
topic |
Cardiomyopathy, Diastole, Hypertrophy |
url |
http://www.pagepress.org/journals/index.php/hi/article/view/1891 |
work_keys_str_mv |
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