SMILE Platform: An Innovative Microfluidic Approach for On-Chip Sample Manipulation and Analysis in Oral Cancer Diagnosis
Oral cancer belongs to the group of head and neck cancers, and, despite its large diffusion, it suffers from low consideration in terms of prevention and early diagnosis. The main objective of the SMILE platform is the development of a low-cost device for oral cancer early screening with features of...
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doaj-c8e0367998d44c379d0fb5f031f54af02021-08-26T14:04:51ZengMDPI AGMicromachines2072-666X2021-07-011288588510.3390/mi12080885SMILE Platform: An Innovative Microfluidic Approach for On-Chip Sample Manipulation and Analysis in Oral Cancer DiagnosisSofia Zoupanou0Annalisa Volpe1Elisabetta Primiceri2Caterina Gaudiuso3Antonio Ancona4Francesco Ferrara5Maria Serena Chiriacò6Department of Mathematics & Physics E. de Giorgi, University of Salento, Via Arnesano, 73100 Lecce, ItalyPhysics Department, University of Bari “Aldo Moro”, Via Orabona 4, 70126 Bari, ItalyCNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, ItalyPhysics Department, University of Bari “Aldo Moro”, Via Orabona 4, 70126 Bari, ItalyPhysics Department, University of Bari “Aldo Moro”, Via Orabona 4, 70126 Bari, ItalyCNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, ItalyCNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, ItalyOral cancer belongs to the group of head and neck cancers, and, despite its large diffusion, it suffers from low consideration in terms of prevention and early diagnosis. The main objective of the SMILE platform is the development of a low-cost device for oral cancer early screening with features of high sensitivity, specificity, and ease of use, with the aim of reaching a large audience of possible users and realizing real prevention of the disease. To achieve this goal, we realized two microfluidic devices exploiting low-cost materials and processes. They can be used in combination or alone to obtain on-chip sample preparation and/or detection of circulating tumor cells, selected as biomarkers of oral cancer. The realized devices are completely transparent with plug-and-play features, obtained thanks to a highly customized architecture which enables users to easily use them, with potential for a common use among physicians or dentists with minimal training.https://www.mdpi.com/2072-666X/12/8/885oral cancercirculating tumor cellsmicromixers3D microfluidicsbiodetectionplastic microfluidics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sofia Zoupanou Annalisa Volpe Elisabetta Primiceri Caterina Gaudiuso Antonio Ancona Francesco Ferrara Maria Serena Chiriacò |
spellingShingle |
Sofia Zoupanou Annalisa Volpe Elisabetta Primiceri Caterina Gaudiuso Antonio Ancona Francesco Ferrara Maria Serena Chiriacò SMILE Platform: An Innovative Microfluidic Approach for On-Chip Sample Manipulation and Analysis in Oral Cancer Diagnosis Micromachines oral cancer circulating tumor cells micromixers 3D microfluidics biodetection plastic microfluidics |
author_facet |
Sofia Zoupanou Annalisa Volpe Elisabetta Primiceri Caterina Gaudiuso Antonio Ancona Francesco Ferrara Maria Serena Chiriacò |
author_sort |
Sofia Zoupanou |
title |
SMILE Platform: An Innovative Microfluidic Approach for On-Chip Sample Manipulation and Analysis in Oral Cancer Diagnosis |
title_short |
SMILE Platform: An Innovative Microfluidic Approach for On-Chip Sample Manipulation and Analysis in Oral Cancer Diagnosis |
title_full |
SMILE Platform: An Innovative Microfluidic Approach for On-Chip Sample Manipulation and Analysis in Oral Cancer Diagnosis |
title_fullStr |
SMILE Platform: An Innovative Microfluidic Approach for On-Chip Sample Manipulation and Analysis in Oral Cancer Diagnosis |
title_full_unstemmed |
SMILE Platform: An Innovative Microfluidic Approach for On-Chip Sample Manipulation and Analysis in Oral Cancer Diagnosis |
title_sort |
smile platform: an innovative microfluidic approach for on-chip sample manipulation and analysis in oral cancer diagnosis |
publisher |
MDPI AG |
series |
Micromachines |
issn |
2072-666X |
publishDate |
2021-07-01 |
description |
Oral cancer belongs to the group of head and neck cancers, and, despite its large diffusion, it suffers from low consideration in terms of prevention and early diagnosis. The main objective of the SMILE platform is the development of a low-cost device for oral cancer early screening with features of high sensitivity, specificity, and ease of use, with the aim of reaching a large audience of possible users and realizing real prevention of the disease. To achieve this goal, we realized two microfluidic devices exploiting low-cost materials and processes. They can be used in combination or alone to obtain on-chip sample preparation and/or detection of circulating tumor cells, selected as biomarkers of oral cancer. The realized devices are completely transparent with plug-and-play features, obtained thanks to a highly customized architecture which enables users to easily use them, with potential for a common use among physicians or dentists with minimal training. |
topic |
oral cancer circulating tumor cells micromixers 3D microfluidics biodetection plastic microfluidics |
url |
https://www.mdpi.com/2072-666X/12/8/885 |
work_keys_str_mv |
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