Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging
Early life stress (ELS) is strongly associated with psychiatric disorders such as anxiety, depression, and schizophrenia in adulthood. To date, biological, behavioral, and structural aspects of ELS have been studied extensively, but their functional effects remain unclear. Here, we examined NeuroPET...
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doaj-c8e1f068ac974fb09b4e0286d56ee6af2021-03-04T00:01:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01222522252210.3390/ijms22052522Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular ImagingNamhun Lee0Se-Jong Oh1Jang-Woo Park2Kyung-Rok Nam3Kyung-Jun Kang4Kyo-Chul Lee5Yong-Jin Lee6June-Seek Choi7Jeong-Ho Seok8Jae-Yong Choi9Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul 01812, KoreaDivision of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul 01812, KoreaKorea Drug Development Platform Using Radio-Isotope, Korea Institute of Radiological and Medical Sciences, Seoul 01812, KoreaDivision of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul 01812, KoreaDivision of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul 01812, KoreaDivision of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul 01812, KoreaDivision of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul 01812, KoreaDepartment of Psychology, Korea University, Seoul 02841, KoreaDepartment of Psychology, Yonsei University, Seoul 06273, KoreaDivision of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul 01812, KoreaEarly life stress (ELS) is strongly associated with psychiatric disorders such as anxiety, depression, and schizophrenia in adulthood. To date, biological, behavioral, and structural aspects of ELS have been studied extensively, but their functional effects remain unclear. Here, we examined NeuroPET studies of dopaminergic, glutamatergic, and serotonergic systems in ELS animal models. Maternal separation and restraint stress were used to generate single or complex developmental trauma. Body weights of animals exposed to single trauma were similar to those of control animals; however, animals exposed to complex trauma exhibited loss of body weight when compared to controls. In behavioral tests, the complex developmental trauma group exhibited a decrease in time spent in the open arm of the elevated plus-maze and an increase in immobility time in the forced swim test when compared to control animals. In NeuroPET studies, the complex trauma group displayed a reduction in brain uptake values when compared to single trauma and control groups. Of neurotransmitter systems analyzed, the rate of decrease in brain uptake was the highest in the serotonergic group. Collectively, our results indicate that developmental trauma events induce behavioral deficits, including anxiety- and depressive-like phenotypes and dysfunction in neurotransmitter systems.https://www.mdpi.com/1422-0067/22/5/2522traumaearly life stressneurotransmissionpositron emission tomography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Namhun Lee Se-Jong Oh Jang-Woo Park Kyung-Rok Nam Kyung-Jun Kang Kyo-Chul Lee Yong-Jin Lee June-Seek Choi Jeong-Ho Seok Jae-Yong Choi |
spellingShingle |
Namhun Lee Se-Jong Oh Jang-Woo Park Kyung-Rok Nam Kyung-Jun Kang Kyo-Chul Lee Yong-Jin Lee June-Seek Choi Jeong-Ho Seok Jae-Yong Choi Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging International Journal of Molecular Sciences trauma early life stress neurotransmission positron emission tomography |
author_facet |
Namhun Lee Se-Jong Oh Jang-Woo Park Kyung-Rok Nam Kyung-Jun Kang Kyo-Chul Lee Yong-Jin Lee June-Seek Choi Jeong-Ho Seok Jae-Yong Choi |
author_sort |
Namhun Lee |
title |
Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging |
title_short |
Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging |
title_full |
Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging |
title_fullStr |
Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging |
title_full_unstemmed |
Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging |
title_sort |
evaluation of the effects of developmental trauma on neurotransmitter systems using functional molecular imaging |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-03-01 |
description |
Early life stress (ELS) is strongly associated with psychiatric disorders such as anxiety, depression, and schizophrenia in adulthood. To date, biological, behavioral, and structural aspects of ELS have been studied extensively, but their functional effects remain unclear. Here, we examined NeuroPET studies of dopaminergic, glutamatergic, and serotonergic systems in ELS animal models. Maternal separation and restraint stress were used to generate single or complex developmental trauma. Body weights of animals exposed to single trauma were similar to those of control animals; however, animals exposed to complex trauma exhibited loss of body weight when compared to controls. In behavioral tests, the complex developmental trauma group exhibited a decrease in time spent in the open arm of the elevated plus-maze and an increase in immobility time in the forced swim test when compared to control animals. In NeuroPET studies, the complex trauma group displayed a reduction in brain uptake values when compared to single trauma and control groups. Of neurotransmitter systems analyzed, the rate of decrease in brain uptake was the highest in the serotonergic group. Collectively, our results indicate that developmental trauma events induce behavioral deficits, including anxiety- and depressive-like phenotypes and dysfunction in neurotransmitter systems. |
topic |
trauma early life stress neurotransmission positron emission tomography |
url |
https://www.mdpi.com/1422-0067/22/5/2522 |
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