Multimodal MRI of grey matter, white matter, and functional connectivity in cognitively healthy mutation carriers at risk for frontotemporal dementia and Alzheimer's disease

Multimodal MRI of grey matter, white matter, and functional connectivity in cognitively healthy mutation carriers at risk for frontotemporal dementia and Alzheimer's disease

Abstract Background Frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are associated with divergent differences in grey matter volume, white matter diffusion, and functional connectivity. However, it is unknown at what disease stage these differences emerge. Here, we investigate whether div...

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Bibliographic Details
Main Authors: Rogier A. Feis, Mark J. R. J. Bouts, Elise G. P. Dopper, Nicola Filippini, Verena Heise, Aaron J. Trachtenberg, John C. van Swieten, Mark A. van Buchem, Jeroen van der Grond, Clare E. Mackay, Serge A. R. B. Rombouts
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Neurology
Subjects:
Microtubule-associated protein tau
progranulin
Apolipoprotein E4
Voxel-based morphometry (VBM)
diffusion tensor imaging (DTI)
Tract-based spatial statistics (TBSS)
Online Access:https://doi.org/10.1186/s12883-019-1567-0

Internet

https://doi.org/10.1186/s12883-019-1567-0

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