Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy
The anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is a marker of clinically amyopathic dermatomyositis (CADM) and rapidly progressive interstitial lung disease (ILD) with acute respiratory failure. A 35-year-old woman with cervical cancer showed Gottron's papules, severe hypo...
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doaj-c8f0ede8d36448b0b3cb34a0d2865eb62020-11-24T23:02:08ZengElsevierRespiratory Medicine Case Reports2213-00712017-01-0120C515410.1016/j.rmcr.2016.11.015Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapyHidenori IchiyasuYasumiko SakamotoChieko YoshidaKazuhiko SakamotoRyosuke FujitaGo NakayamaHiroko OkabayashiSho SaekiShinichiro OkamotoHirotsugu KohrogiThe anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is a marker of clinically amyopathic dermatomyositis (CADM) and rapidly progressive interstitial lung disease (ILD) with acute respiratory failure. A 35-year-old woman with cervical cancer showed Gottron's papules, severe hypoxemia, and diffuse ground-glass opacities on chest computed tomography. She was diagnosed with rapidly progressive ILD associated with CADM. Her serum was positive for the anti-MDA-5 antibody. Combination therapy with corticosteroids, immunosuppressants, and direct hemoperfusion using polymyxin B-immobilized fiber column (PMX-DHP) improved her respiratory dysfunction. Eventually, surgery for the cancer was performed successfully. This is the first case to demonstrate the efficacy of PMX-DHP for rapidly progressive ILD with anti-MDA-5 antibody-positive CADM and a malignancy.http://www.sciencedirect.com/science/article/pii/S2213007116301757Anti-melanoma differentiation-associated gene 5 antibodyClinically amyopathic dermatomyositisRapidly progressive interstitial lung diseaseDirect hemoperfusion using polymyxin B-immobilized fiber columnCervical cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hidenori Ichiyasu Yasumiko Sakamoto Chieko Yoshida Kazuhiko Sakamoto Ryosuke Fujita Go Nakayama Hiroko Okabayashi Sho Saeki Shinichiro Okamoto Hirotsugu Kohrogi |
spellingShingle |
Hidenori Ichiyasu Yasumiko Sakamoto Chieko Yoshida Kazuhiko Sakamoto Ryosuke Fujita Go Nakayama Hiroko Okabayashi Sho Saeki Shinichiro Okamoto Hirotsugu Kohrogi Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy Respiratory Medicine Case Reports Anti-melanoma differentiation-associated gene 5 antibody Clinically amyopathic dermatomyositis Rapidly progressive interstitial lung disease Direct hemoperfusion using polymyxin B-immobilized fiber column Cervical cancer |
author_facet |
Hidenori Ichiyasu Yasumiko Sakamoto Chieko Yoshida Kazuhiko Sakamoto Ryosuke Fujita Go Nakayama Hiroko Okabayashi Sho Saeki Shinichiro Okamoto Hirotsugu Kohrogi |
author_sort |
Hidenori Ichiyasu |
title |
Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy |
title_short |
Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy |
title_full |
Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy |
title_fullStr |
Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy |
title_full_unstemmed |
Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy |
title_sort |
rapidly progressive interstitial lung disease due to anti-mda-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: successful treatment with direct hemoperfusion using polymyxin b-immobilized fiber column therapy |
publisher |
Elsevier |
series |
Respiratory Medicine Case Reports |
issn |
2213-0071 |
publishDate |
2017-01-01 |
description |
The anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is a marker of clinically amyopathic dermatomyositis (CADM) and rapidly progressive interstitial lung disease (ILD) with acute respiratory failure. A 35-year-old woman with cervical cancer showed Gottron's papules, severe hypoxemia, and diffuse ground-glass opacities on chest computed tomography. She was diagnosed with rapidly progressive ILD associated with CADM. Her serum was positive for the anti-MDA-5 antibody. Combination therapy with corticosteroids, immunosuppressants, and direct hemoperfusion using polymyxin B-immobilized fiber column (PMX-DHP) improved her respiratory dysfunction. Eventually, surgery for the cancer was performed successfully. This is the first case to demonstrate the efficacy of PMX-DHP for rapidly progressive ILD with anti-MDA-5 antibody-positive CADM and a malignancy. |
topic |
Anti-melanoma differentiation-associated gene 5 antibody Clinically amyopathic dermatomyositis Rapidly progressive interstitial lung disease Direct hemoperfusion using polymyxin B-immobilized fiber column Cervical cancer |
url |
http://www.sciencedirect.com/science/article/pii/S2213007116301757 |
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