Antiviral activity of herbal extracts against the tick borne encephalitis virus (literature review)
Tick-borne encephalitis (TBE) is a widely known viral disease that is transmitted through the bites of ixodid ticks. In severe cases, it leads to disability or death of the patient. The causative agent of the TBE is the tick-borne encephalitis virus (TBEV), which belongs to the Flaviviridae family....
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Scientific Сentre for Family Health and Human Reproduction Problems
2017-09-01
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doaj-c8f3caa5102244f1900ac7845d7c9d5b2021-08-17T13:52:58ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962017-09-0125(1)939910.12737/article_59e8590672ae06.68650343439Antiviral activity of herbal extracts against the tick borne encephalitis virus (literature review)I. S. Solovarov0M. A. Khasnatinov1A. V. Liapunov2E. L. Manzarova3N. A. Bolotova4N. .. Oyuntsetseg5G. A. Danchinova6Scientific Centre for Family Health and Human Reproduction ProblemsScientific Centre for Family Health and Human Reproduction ProblemsScientific Centre for Family Health and Human Reproduction ProblemsScientific Centre for Family Health and Human Reproduction ProblemsScientific Centre for Family Health and Human Reproduction ProblemsInstitute of Traditional Medicine, Mongolian National University of Medical SciencesScientific Centre for Family Health and Human Reproduction ProblemsTick-borne encephalitis (TBE) is a widely known viral disease that is transmitted through the bites of ixodid ticks. In severe cases, it leads to disability or death of the patient. The causative agent of the TBE is the tick-borne encephalitis virus (TBEV), which belongs to the Flaviviridae family. Despite the great importance of TBE in human pathology, currently the only way to prevent and treat this disease is a donor immunoglobulin, which has a number of significant disadvantages. In this paper, we analyzed modern literature on the detection of antiviral properties of herbal preparations and assessed the possibility of using them to search for new drugs against TBE. In general, the published works can be divided into two areas of research - the study of whole plant extracts and the study of the biological activity of the purified extract components. The most informative results can be obtained under certain conditions; for example, the study of both water extracts of plants and extracts with organic solvents, fractionation of the initial preparations with the detected antiviral activity followed by the concentration of the target substance; identification of an antiviral agent to obtain standardized drugs and preclinical testing in laboratory animals and cell cultures. This approach made it possible to identify three substances - hebulinic acid, panicalagin and baikalein - possessing inhibitory activity against Dengue flavivirus. The article discusses the possibility of using these substances against TBEV and the optimal algorithm for searching for antiviral agents in plant preparations.https://www.actabiomedica.ru/jour/article/view/439terminalia chebulatick-borne encephalitis virusherbal extractst. chebula |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
I. S. Solovarov M. A. Khasnatinov A. V. Liapunov E. L. Manzarova N. A. Bolotova N. .. Oyuntsetseg G. A. Danchinova |
spellingShingle |
I. S. Solovarov M. A. Khasnatinov A. V. Liapunov E. L. Manzarova N. A. Bolotova N. .. Oyuntsetseg G. A. Danchinova Antiviral activity of herbal extracts against the tick borne encephalitis virus (literature review) Acta Biomedica Scientifica terminalia chebula tick-borne encephalitis virus herbal extracts t. chebula |
author_facet |
I. S. Solovarov M. A. Khasnatinov A. V. Liapunov E. L. Manzarova N. A. Bolotova N. .. Oyuntsetseg G. A. Danchinova |
author_sort |
I. S. Solovarov |
title |
Antiviral activity of herbal extracts against the tick borne encephalitis virus (literature review) |
title_short |
Antiviral activity of herbal extracts against the tick borne encephalitis virus (literature review) |
title_full |
Antiviral activity of herbal extracts against the tick borne encephalitis virus (literature review) |
title_fullStr |
Antiviral activity of herbal extracts against the tick borne encephalitis virus (literature review) |
title_full_unstemmed |
Antiviral activity of herbal extracts against the tick borne encephalitis virus (literature review) |
title_sort |
antiviral activity of herbal extracts against the tick borne encephalitis virus (literature review) |
publisher |
Scientific Сentre for Family Health and Human Reproduction Problems |
series |
Acta Biomedica Scientifica |
issn |
2541-9420 2587-9596 |
publishDate |
2017-09-01 |
description |
Tick-borne encephalitis (TBE) is a widely known viral disease that is transmitted through the bites of ixodid ticks. In severe cases, it leads to disability or death of the patient. The causative agent of the TBE is the tick-borne encephalitis virus (TBEV), which belongs to the Flaviviridae family. Despite the great importance of TBE in human pathology, currently the only way to prevent and treat this disease is a donor immunoglobulin, which has a number of significant disadvantages. In this paper, we analyzed modern literature on the detection of antiviral properties of herbal preparations and assessed the possibility of using them to search for new drugs against TBE. In general, the published works can be divided into two areas of research - the study of whole plant extracts and the study of the biological activity of the purified extract components. The most informative results can be obtained under certain conditions; for example, the study of both water extracts of plants and extracts with organic solvents, fractionation of the initial preparations with the detected antiviral activity followed by the concentration of the target substance; identification of an antiviral agent to obtain standardized drugs and preclinical testing in laboratory animals and cell cultures. This approach made it possible to identify three substances - hebulinic acid, panicalagin and baikalein - possessing inhibitory activity against Dengue flavivirus. The article discusses the possibility of using these substances against TBEV and the optimal algorithm for searching for antiviral agents in plant preparations. |
topic |
terminalia chebula tick-borne encephalitis virus herbal extracts t. chebula |
url |
https://www.actabiomedica.ru/jour/article/view/439 |
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