Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition
Abstract Introduction Relationship between self– and informant memory concerns and tau aggregation was assessed in adults at risk for Alzheimer's disease (AD). Methods Regional mean standardized uptake value ratios were extracted from [18F]flortaucipir positron emission tomography (PET) scans o...
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doaj-c8f4ca74dd6d4b7cb122c67322f4e9392020-11-25T03:24:24ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292018-01-0110132233110.1016/j.dadm.2018.03.001Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau depositionCecily G. Swinford0Shannon L. Risacher1Arnaud Charil2Adam J. Schwarz3Andrew J. Saykin4Alzheimer's Disease Neuroimaging Initiative5Department of Radiology and Imaging SciencesCenter for Neuroimaging, Indiana University School of MedicineIndianapolisINUSADepartment of Radiology and Imaging SciencesCenter for Neuroimaging, Indiana University School of MedicineIndianapolisINUSAEli Lilly and CompanyIndianapolisINUSADepartment of Radiology and Imaging SciencesCenter for Neuroimaging, Indiana University School of MedicineIndianapolisINUSADepartment of Radiology and Imaging SciencesCenter for Neuroimaging, Indiana University School of MedicineIndianapolisINUSADepartment of Radiology and Imaging SciencesCenter for Neuroimaging, Indiana University School of MedicineIndianapolisINUSAAbstract Introduction Relationship between self– and informant memory concerns and tau aggregation was assessed in adults at risk for Alzheimer's disease (AD). Methods Regional mean standardized uptake value ratios were extracted from [18F]flortaucipir positron emission tomography (PET) scans of 82 at‐risk adults in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Associations between self– and informant ECog memory scores and tau aggregation were analyzed on both regional and voxelwise bases. Analyses were completed both on the whole sample and restricted to amyloid‐positive individuals only. Results Memory concerns were associated with tau aggregation. Self‐perception was more associated with frontal tau. In contrast, informant scores were more associated with parietal tau. This source‐by‐region interaction was more prominent in amyloid‐positive participants and observed in both regional and voxelwise analyses. Discussion Quantitative assessment of perceived memory functioning may be useful for screening older adults at risk for Alzheimer's disease. Individuals and their informants may provide complementary information relating to the anatomical distribution of tau.https://doi.org/10.1016/j.dadm.2018.03.001Significant memory concernSMCSubjective cognitive declineSCDEarly mild cognitive impairmentEMCI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cecily G. Swinford Shannon L. Risacher Arnaud Charil Adam J. Schwarz Andrew J. Saykin Alzheimer's Disease Neuroimaging Initiative |
spellingShingle |
Cecily G. Swinford Shannon L. Risacher Arnaud Charil Adam J. Schwarz Andrew J. Saykin Alzheimer's Disease Neuroimaging Initiative Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Significant memory concern SMC Subjective cognitive decline SCD Early mild cognitive impairment EMCI |
author_facet |
Cecily G. Swinford Shannon L. Risacher Arnaud Charil Adam J. Schwarz Andrew J. Saykin Alzheimer's Disease Neuroimaging Initiative |
author_sort |
Cecily G. Swinford |
title |
Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition |
title_short |
Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition |
title_full |
Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition |
title_fullStr |
Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition |
title_full_unstemmed |
Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition |
title_sort |
memory concerns in the early alzheimer's disease prodrome: regional association with tau deposition |
publisher |
Wiley |
series |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
issn |
2352-8729 |
publishDate |
2018-01-01 |
description |
Abstract Introduction Relationship between self– and informant memory concerns and tau aggregation was assessed in adults at risk for Alzheimer's disease (AD). Methods Regional mean standardized uptake value ratios were extracted from [18F]flortaucipir positron emission tomography (PET) scans of 82 at‐risk adults in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Associations between self– and informant ECog memory scores and tau aggregation were analyzed on both regional and voxelwise bases. Analyses were completed both on the whole sample and restricted to amyloid‐positive individuals only. Results Memory concerns were associated with tau aggregation. Self‐perception was more associated with frontal tau. In contrast, informant scores were more associated with parietal tau. This source‐by‐region interaction was more prominent in amyloid‐positive participants and observed in both regional and voxelwise analyses. Discussion Quantitative assessment of perceived memory functioning may be useful for screening older adults at risk for Alzheimer's disease. Individuals and their informants may provide complementary information relating to the anatomical distribution of tau. |
topic |
Significant memory concern SMC Subjective cognitive decline SCD Early mild cognitive impairment EMCI |
url |
https://doi.org/10.1016/j.dadm.2018.03.001 |
work_keys_str_mv |
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