Hemodynamic and Morphological Parameters of Ruptured Mirror Posterior Communicating Artery Aneurysms
Objective: Morphological and hemodynamic parameters might predict rupture of intracranial aneurysms (IAs). A practical model for the study is patients with ruptured mirror IAs in which one is ruptured and the other is unruptured. Although there have been analyses of the morphology and hemodynamics o...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2021-09-01
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Series: | Frontiers in Neurology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.653589/full |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jinlong Yuan Chenlei Huang Zhenbao Li Xiaochun Jiang Xintong Zhao Degang Wu Nianshen Lai Jiaqiang Liu Bingbing Zhang Feiyun Qin Dayong Xia Xinggen Fang |
spellingShingle |
Jinlong Yuan Chenlei Huang Zhenbao Li Xiaochun Jiang Xintong Zhao Degang Wu Nianshen Lai Jiaqiang Liu Bingbing Zhang Feiyun Qin Dayong Xia Xinggen Fang Hemodynamic and Morphological Parameters of Ruptured Mirror Posterior Communicating Artery Aneurysms Frontiers in Neurology computational fluid dynamic hemodynamics morphological mirror aneurysms posterior communicating artery |
author_facet |
Jinlong Yuan Chenlei Huang Zhenbao Li Xiaochun Jiang Xintong Zhao Degang Wu Nianshen Lai Jiaqiang Liu Bingbing Zhang Feiyun Qin Dayong Xia Xinggen Fang |
author_sort |
Jinlong Yuan |
title |
Hemodynamic and Morphological Parameters of Ruptured Mirror Posterior Communicating Artery Aneurysms |
title_short |
Hemodynamic and Morphological Parameters of Ruptured Mirror Posterior Communicating Artery Aneurysms |
title_full |
Hemodynamic and Morphological Parameters of Ruptured Mirror Posterior Communicating Artery Aneurysms |
title_fullStr |
Hemodynamic and Morphological Parameters of Ruptured Mirror Posterior Communicating Artery Aneurysms |
title_full_unstemmed |
Hemodynamic and Morphological Parameters of Ruptured Mirror Posterior Communicating Artery Aneurysms |
title_sort |
hemodynamic and morphological parameters of ruptured mirror posterior communicating artery aneurysms |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2021-09-01 |
description |
Objective: Morphological and hemodynamic parameters might predict rupture of intracranial aneurysms (IAs). A practical model for the study is patients with ruptured mirror IAs in which one is ruptured and the other is unruptured. Although there have been analyses of the morphology and hemodynamics of ruptured mirror posterior communicating artery aneurysms (PComAAs), the sample sizes in these studies were small and only considered hemodynamics or morphological characters. Therefore, this study aimed to investigate the morphological and hemodynamic parameters associated with ruptured mirror PComAAs.Methods: We considered 72 patients with ruptured mirror PComAAs using computational fluid dynamics (CFDs). Ruptured mirror PComAAs were divided into ruptured and unruptured groups. Fourteen morphological and eight hemodynamic parameters were calculated and compared. Significant parameters were analyzed by the multivariate logistic regression to identify independent risk factors. Receiver operating characteristic (ROC) analysis was performed, and the area under the ROC curve (AUC) was calculated for all independent risk factors to determine the predictability and identify the optimal threshold.Results: Four hemodynamic and three morphological parameters were significantly different between ruptured and unruptured groups: normalized wall shear stress (NWSS), mean WSS, low wall shear WSS area (LSA%), size, aspect ratio (AR), size ratio (SR), and inflow angle (IA). Multivariate logistic regression analysis showed that AR, SR, NWSS, mean WSS, and LSA% were all independent factors significantly associated with PComAAs rupture. The ROC analysis for independent risk factors indicated that AR (0.751), NWSS (0.755), mean WSS (0.69), and LSA (0.778) had merely acceptable AUC values. Only SR (0.803) had a high acceptable AUC value. The threshold value of SR was 1.96.Conclusions: SR (>1.96) was the most significant parameter associated with IA rupture, whereas AR, NWSS, mean WSS, and LSA independently characterized the status of IA rupture. |
topic |
computational fluid dynamic hemodynamics morphological mirror aneurysms posterior communicating artery |
url |
https://www.frontiersin.org/articles/10.3389/fneur.2021.653589/full |
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doaj-c9020347e6654ee48c8e4752e3c104702021-09-27T15:19:05ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-09-011210.3389/fneur.2021.653589653589Hemodynamic and Morphological Parameters of Ruptured Mirror Posterior Communicating Artery AneurysmsJinlong Yuan0Chenlei Huang1Zhenbao Li2Xiaochun Jiang3Xintong Zhao4Degang Wu5Nianshen Lai6Jiaqiang Liu7Bingbing Zhang8Feiyun Qin9Dayong Xia10Xinggen Fang11Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, ChinaObjective: Morphological and hemodynamic parameters might predict rupture of intracranial aneurysms (IAs). A practical model for the study is patients with ruptured mirror IAs in which one is ruptured and the other is unruptured. Although there have been analyses of the morphology and hemodynamics of ruptured mirror posterior communicating artery aneurysms (PComAAs), the sample sizes in these studies were small and only considered hemodynamics or morphological characters. Therefore, this study aimed to investigate the morphological and hemodynamic parameters associated with ruptured mirror PComAAs.Methods: We considered 72 patients with ruptured mirror PComAAs using computational fluid dynamics (CFDs). Ruptured mirror PComAAs were divided into ruptured and unruptured groups. Fourteen morphological and eight hemodynamic parameters were calculated and compared. Significant parameters were analyzed by the multivariate logistic regression to identify independent risk factors. Receiver operating characteristic (ROC) analysis was performed, and the area under the ROC curve (AUC) was calculated for all independent risk factors to determine the predictability and identify the optimal threshold.Results: Four hemodynamic and three morphological parameters were significantly different between ruptured and unruptured groups: normalized wall shear stress (NWSS), mean WSS, low wall shear WSS area (LSA%), size, aspect ratio (AR), size ratio (SR), and inflow angle (IA). Multivariate logistic regression analysis showed that AR, SR, NWSS, mean WSS, and LSA% were all independent factors significantly associated with PComAAs rupture. The ROC analysis for independent risk factors indicated that AR (0.751), NWSS (0.755), mean WSS (0.69), and LSA (0.778) had merely acceptable AUC values. Only SR (0.803) had a high acceptable AUC value. The threshold value of SR was 1.96.Conclusions: SR (>1.96) was the most significant parameter associated with IA rupture, whereas AR, NWSS, mean WSS, and LSA independently characterized the status of IA rupture.https://www.frontiersin.org/articles/10.3389/fneur.2021.653589/fullcomputational fluid dynamichemodynamicsmorphologicalmirror aneurysmsposterior communicating artery |