Interferon‐γ‐induced HLA Class II expression on endothelial cells is decreased by inhibition of mTOR and HMG‐CoA reductase

Interferon‐γ‐induced HLA Class II expression on endothelial cells is decreased by inhibition of mTOR and HMG‐CoA reductase

In organ transplantation, donor‐specific HLA antibody (DSA) is considered a major cause of graft rejection. Because DSA targets primarily donor‐specific human leukocyte antigen (HLA) expressed on graft endothelial cells, the prevention of its expression is a possible strategy for avoiding or salvagi...

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Bibliographic Details
Main Authors: Akihiro Maenaka, Iwasaki Kenta, Akinobu Ota, Yuko Miwa, Wataru Ohashi, Kosei Horimi, Yutaka Matsuoka, Masafumi Ohnishi, Kazuharu Uchida, Takaaki Kobayashi
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:FEBS Open Bio
Subjects:
CIITA
endothelial cell
everolimus
fluvastatin
HLA class II
Online Access:https://doi.org/10.1002/2211-5463.12854

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