The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2

The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2

FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2-FANCI complex, providing insight into how the complex is recruited to stalled replication forks.

Bibliographic Details
Main Authors: Chih-Chao Liang, Zhuolun Li, David Lopez-Martinez, William V. Nicholson, Catherine Vénien-Bryan, Martin A. Cohn
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12124
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spelling doaj-c919cf65091d44ba84e82fd2b5331de62021-05-11T11:05:09ZengNature Publishing GroupNature Communications2041-17232016-07-017111010.1038/ncomms12124The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2Chih-Chao Liang0Zhuolun Li1David Lopez-Martinez2William V. Nicholson3Catherine Vénien-Bryan4Martin A. Cohn5Department of Biochemistry, University of OxfordInstitute of Mineralogy, Materials Physics and Cosmochemistry, UMR 7590, UPMC, CNRS, IRD, MNHNDepartment of Biochemistry, University of OxfordDepartment of Biochemistry, University of OxfordInstitute of Mineralogy, Materials Physics and Cosmochemistry, UMR 7590, UPMC, CNRS, IRD, MNHNDepartment of Biochemistry, University of OxfordFANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2-FANCI complex, providing insight into how the complex is recruited to stalled replication forks.https://doi.org/10.1038/ncomms12124
collection DOAJ
language English
format Article
sources DOAJ
author Chih-Chao Liang
Zhuolun Li
David Lopez-Martinez
William V. Nicholson
Catherine Vénien-Bryan
Martin A. Cohn
spellingShingle Chih-Chao Liang
Zhuolun Li
David Lopez-Martinez
William V. Nicholson
Catherine Vénien-Bryan
Martin A. Cohn
The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
Nature Communications
author_facet Chih-Chao Liang
Zhuolun Li
David Lopez-Martinez
William V. Nicholson
Catherine Vénien-Bryan
Martin A. Cohn
author_sort Chih-Chao Liang
title The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
title_short The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
title_full The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
title_fullStr The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
title_full_unstemmed The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
title_sort fancd2–fanci complex is recruited to dna interstrand crosslinks before monoubiquitination of fancd2
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-07-01
description FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2-FANCI complex, providing insight into how the complex is recruited to stalled replication forks.
url https://doi.org/10.1038/ncomms12124
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