Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population
Breast cancer (BC) is one of the most frequent tumors affecting women worldwide. microRNAs (miRNAs) single-nucleotide polymorphisms (SNPs) likely contribute to BC susceptibility. We evaluated the association of five SNPs with BC risk in non-carriers of the BRCA1/2-mutation from a South American popu...
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doaj-c92de2d2d6424aafa570451e674b0a4c2020-11-25T01:06:00ZengMDPI AGGenes2073-44252018-08-019942710.3390/genes9090427genes9090427Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American PopulationSebastián Morales0Tomas De Mayo1Felipe Andrés Gulppi2Patricio Gonzalez-Hormazabal3Valentina Carrasco4José Miguel Reyes5Fernando Gómez6Enrique Waugh7Lilian Jara8Human Genetics Program, Institute of Biomedical Sciences (ICBM), School of Medicine, University of Chile, Santiago 8380453, ChileCenter for Genetics and Genomics, School of Medicine, Clínica Alemana Universidad del Desarrollo, Santiago 7610658, ChileHuman Genetics Program, Institute of Biomedical Sciences (ICBM), School of Medicine, University of Chile, Santiago 8380453, ChileHuman Genetics Program, Institute of Biomedical Sciences (ICBM), School of Medicine, University of Chile, Santiago 8380453, ChileHuman Genetics Program, Institute of Biomedical Sciences (ICBM), School of Medicine, University of Chile, Santiago 8380453, ChileClínica Las Condes, Santiago 7591047, ChileClínica Santa María, Santiago 7520378, ChileClínica Santa María, Santiago 7520378, ChileHuman Genetics Program, Institute of Biomedical Sciences (ICBM), School of Medicine, University of Chile, Santiago 8380453, ChileBreast cancer (BC) is one of the most frequent tumors affecting women worldwide. microRNAs (miRNAs) single-nucleotide polymorphisms (SNPs) likely contribute to BC susceptibility. We evaluated the association of five SNPs with BC risk in non-carriers of the BRCA1/2-mutation from a South American population. The SNPs were genotyped in 440 Chilean BRCA1/2-negative BC cases and 1048 controls. Our data do not support an association between rs2910164:G>C or rs3746444:A>G and BC risk. The rs12975333:G>T is monomorphic in the Chilean population. The pre-miR-605 rs2043556-C allele was associated with a decreased risk of BC, both in patients with a strong family history of BC and in early-onset non-familial BC (Odds ratio (OR) = 0.5 [95% confidence interval (CI) 0.4–0.9] p = 0.006 and OR = 0.6 [95% CI 0.5–0.9] p = 0.02, respectively). The rs4541843-T allele is associated with increased risk of familial BC. This is the first association study on rs4541843 and BC risk. Previously, we showed that the TOX3-rs3803662:C>T was significantly associated with increased risk of familial BC. Given that TOX3 mRNA is a target of miR-182, and that both the TOX3 rs3803662-T and pri-miR-182 rs4541843-T alleles are associated with increased BC risk, we evaluated their combined effect. Risk of familial BC increased in a dose-dependent manner with the number of risk alleles (p-trend = 0.0005), indicating an additive effect.http://www.mdpi.com/2073-4425/9/9/427familial breast cancerpolymorphismsmicroRNASouth American population |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sebastián Morales Tomas De Mayo Felipe Andrés Gulppi Patricio Gonzalez-Hormazabal Valentina Carrasco José Miguel Reyes Fernando Gómez Enrique Waugh Lilian Jara |
spellingShingle |
Sebastián Morales Tomas De Mayo Felipe Andrés Gulppi Patricio Gonzalez-Hormazabal Valentina Carrasco José Miguel Reyes Fernando Gómez Enrique Waugh Lilian Jara Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population Genes familial breast cancer polymorphisms microRNA South American population |
author_facet |
Sebastián Morales Tomas De Mayo Felipe Andrés Gulppi Patricio Gonzalez-Hormazabal Valentina Carrasco José Miguel Reyes Fernando Gómez Enrique Waugh Lilian Jara |
author_sort |
Sebastián Morales |
title |
Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population |
title_short |
Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population |
title_full |
Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population |
title_fullStr |
Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population |
title_full_unstemmed |
Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population |
title_sort |
genetic variants in pre-mir-146a, pre-mir-499, pre-mir-125a, pre-mir-605, and pri-mir-182 are associated with breast cancer susceptibility in a south american population |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2018-08-01 |
description |
Breast cancer (BC) is one of the most frequent tumors affecting women worldwide. microRNAs (miRNAs) single-nucleotide polymorphisms (SNPs) likely contribute to BC susceptibility. We evaluated the association of five SNPs with BC risk in non-carriers of the BRCA1/2-mutation from a South American population. The SNPs were genotyped in 440 Chilean BRCA1/2-negative BC cases and 1048 controls. Our data do not support an association between rs2910164:G>C or rs3746444:A>G and BC risk. The rs12975333:G>T is monomorphic in the Chilean population. The pre-miR-605 rs2043556-C allele was associated with a decreased risk of BC, both in patients with a strong family history of BC and in early-onset non-familial BC (Odds ratio (OR) = 0.5 [95% confidence interval (CI) 0.4–0.9] p = 0.006 and OR = 0.6 [95% CI 0.5–0.9] p = 0.02, respectively). The rs4541843-T allele is associated with increased risk of familial BC. This is the first association study on rs4541843 and BC risk. Previously, we showed that the TOX3-rs3803662:C>T was significantly associated with increased risk of familial BC. Given that TOX3 mRNA is a target of miR-182, and that both the TOX3 rs3803662-T and pri-miR-182 rs4541843-T alleles are associated with increased BC risk, we evaluated their combined effect. Risk of familial BC increased in a dose-dependent manner with the number of risk alleles (p-trend = 0.0005), indicating an additive effect. |
topic |
familial breast cancer polymorphisms microRNA South American population |
url |
http://www.mdpi.com/2073-4425/9/9/427 |
work_keys_str_mv |
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