A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism
Summary: The CNS plays a pivotal role in energy homeostasis, but whether oligodendrocytes are involved has been largely unexplored. Here, we show that signaling through GPR17, a G-protein-coupled receptor predominantly expressed in the oligodendrocyte lineage, regulates food intake by modulating hyp...
Main Authors: | Zhimin Ou, Yanchen Ma, Yuxia Sun, Gege Zheng, Shiyun Wang, Rui Xing, Xiang Chen, Ying Han, Jiajia Wang, Q. Richard Lu, Tong-Jin Zhao, Ying Chen |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-03-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719302396 |
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