Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations and clinical outcomes in tuberculous meningitis.

Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations and clinical outcomes in tuberculous meningitis.

BACKGROUND:Adjunctive dexamethasone reduces mortality from tuberculous meningitis, but how it produces this effect is not known. Matrix metalloproteinases (MMPs) are important in the immunopathology of many inflammatory CNS diseases thus we hypothesized that that their secretion is important in TBM...

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Main Authors: Justin A Green, Chau T H Tran, Jeremy J Farrar, Mai T H Nguyen, Phu H Nguyen, Sinh X Dinh, Nghia D T Ho, Chuong V Ly, Hien T Tran, Jon S Friedland, Guy E Thwaites
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2748711?pdf=render

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http://europepmc.org/articles/PMC2748711?pdf=render

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